Organosilicon phantom for photoacoustic imaging

被引：38

作者：

Avigo, Cinzia ^{[1
]}

Di Lascio, Nicole ^{[1
,2
]}

Armanetti, Paolo ^{[3
]}

Kusmic, Claudia ^{[1
]}

Cavigli, Lucia ^{[4
]}

Ratto, Fulvio ^{[4
]}

Meucci, Sandro ^{[5
,6
,7
]}

Masciullo, Cecilia ^{[5
,6
]}

Cecchini, Marco ^{[5
,6
]}

Pini, Roberto

Faita, Francesco ^{[1
]}

Menichetti, Luca ^{[1
,8
]}

机构：

[1] CNR, Ist Fisiol Clin, I-56124 Pisa, Italy

[2] Scuola Super Sant Anna, I-56127 Pisa, Italy

[3] Univ Pisa, Dipartimento Fis, I-56127 Pisa, Italy

[4] CNR, Ist Fis Applicata Nello Carrara, I-50019 Naples, Italy

[5] CNR, Ist Nanosci, NEST, I-56127 Pisa, Italy

[6] Scuola Normale Super Pisa, I-56127 Pisa, Italy

[7] NEST, Ctr Nanotechnol Innovat, Ist Italiano Tecnol, I-56127 Pisa, Italy

[8] Fdn CNR Reg Toscana G Monasterio, I-56124 Pisa, Italy

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2015年 / 20卷 / 04期

关键词：

photoacoustic imaging; phantom; polydimethylsiloxane; agar; contrast agents; GOLD NANORODS; OPTICAL-PROPERTIES; NANOPARTICLES;

D O I：

10.1117/1.JBO.20.4.046008

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

Photoacoustic imaging is an emerging technique. Although commercially available photoacoustic imaging systems currently exist, the technology is still in its infancy. Therefore, the design of stable phantoms is essential to achieve semiquantitative evaluation of the performance of a photoacoustic system and can help optimize the properties of contrast agents. We designed and developed a polydimethylsiloxane (PDMS) phantom with exceptionally fine geometry; the phantom was tested using photoacoustic experiments loaded with the standard indocyanine green dye and compared to an agar phantom pattern through polyethylene glycol-gold nanorods. The linearity of the photoacoustic signal with the nanoparticle number was assessed. The signal-to-noise ratio and contrast were employed as image quality parameters, and enhancements of up to 50 and up to 300%, respectively, were measured with the PDMS phantom with respect to the agar one. A tissue-mimicking (TM)-PDMS was prepared by adding TiO2 and India ink; photoacoustic tests were performed in order to compare the signal generated by the TM-PDMS and the biological tissue. The PDMS phantom can become a particularly promising tool in the field of photoacoustics for the evaluation of the performance of a PA system and as a model of the structure of vascularized soft tissues. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)

引用

页数：7

共 28 条

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Targeted gold nanorod contrast agent for prostate cancer detection by photoacoustic imaging [J].