Synthesis and evaluation of novel 1,5-benzodiazepines as potent and selective CCK-B ligands. Effect of the substitution of the N-5 phenyl with alkyl groups

被引：11

作者：

Finizia, G

Donati, D

Oliosi, B

Tranquillini, ME

Ursini, A

机构：

[1] Glaxo Wellcome S.p.A., Medicines Research Center, 37135 Verona

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(96)00544-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and biological evaluation of both 3-ureido and 3-carbamate derivatives of 1,5-benzodiazepines bearing bulky alkyl substituents at N-1 and N-5 positions is reported. Their activity as CCK-B receptor antagonists is discussed and compared with the related N-5-phenyl derivatives. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2957 / 2962

页数：6

共 23 条

[1]

CORSI M, 1995, BRIT J PHARMACOL, V114, pP91

[2] BIOLOGICAL ACTIONS OF CHOLECYSTOKININ [J].