Facile, efficient approach to accomplish tunable chemistries and variable biodistributions for shell cross-linked nanoparticles

被引：80

作者：

Sun, Guorong ^{[1
]}

Hagooly, Aviv ^{[2
]}

Xu, Jinqi ^{[1
]}

Nystroem, Andreas M. ^{[1
]}

Li, Zicheng ^{[1
]}

Rossin, Raffaella ^{[2
]}

Moore, Dennis A. ^{[3
]}

Wooley, Karen L. ^{[1
,2
]}

Welch, Michael J. ^{[1
,2
]}

机构：

[1] Washington Univ, Dept Chem, St Louis, MO 63130 USA

[2] Washington Univ, Sch Med, Mallinckrodt Inst Radiol, St Louis, MO 63130 USA

[3] Covidien AG, St Louis, MO 63134 USA

来源：

BIOMACROMOLECULES | 2008年 / 9卷 / 07期

关键词：

D O I：

10.1021/bm800246x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The in vivo behavior of shell cross-linked knedel-like (SCK) nanoparticles is shown to be tunable via a straightforward and versatile process that advances SCKs as attractive nanoscale carriers in the field of nanomedicine. Tuning of the pharmacokinetics was accomplished by grafting varied numbers of methoxy-terminated poly(ethylene glycol) (mPEG) chains to the amphiphilic block copolymer precursors, together with chelators for the radioactive tracer and therapeutic agent Cu-64, followed by self-assembly into block copolymer micelles and chemical cross-linking throughout the shell regions. Cu-64-radiolabeling was then performed to evaluate the SCKs in vivo by means of biodistribution experiments and positron emission tomography (PET). It was found that the blood retention of PEGylated SCKs could be tuned, depending on the mPEG grafting density and the nanoparticle surface properties. A semiquantitative model of the density of mPEG surface coverage as a function of in vivo behavior was applied to enhance the understanding of this system.

引用

页码：1997 / 2006

页数：10

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