Association between serotonin transporter gene polymorphism and chronic fatigue syndrome

被引：80

作者：

Narita, M

Nishigami, N

Narita, N

Yamaguti, K

Okado, N

Watanabe, Y

Kuratsune, H

机构：

[1] Osaka City Univ, Grad Sch Med, Dept Physiol, Abeno Ku, Osaka 5458585, Japan

[2] Univ Tsukuba, Inst Basic Med Sci, Tsukuba, Ibaraki 3058575, Japan

[3] Osaka Univ, Grad Sch Med, Dept Mol Med Hematol & Oncol, Suita, Osaka 5650871, Japan

[4] Kansai Univ Welf Sci, Dept Hlth Sci, Kashiwara, Osaka 5820026, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 311卷 / 02期

基金：

日本学术振兴会;

关键词：

chronic fatigue syndrome; CFS; 5-HTT; 5-HT; serotonin; transporter; polymorphism; 5-HTTLPR; HPA axis; PCR;

D O I：

10.1016/j.bbrc.2003.09.207

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interaction between the hypothalamo-pituitary-adrenal axis and the serotonergic system is thought to be disrupted in chronic fatigue syndrome (CFS) patients. We examined a serotonin transporter (5-HTT) gene promoter polymorphism, which affects the transcriptional efficiency of 5-HTT, in 78 CFS patients using PCR amplification of the blood genomic DNA. A significant increase of longer (L and XL) alleic variants was found in the CFS patients compared to the controls both by the genotype-wise and the allele-wise analyses (both p < 0.05, by chi(2) test and Fisher's exact test). Attenuated concentration of extracellular serotonin due to longer variants may cause higher susceptibility to CFS. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：264 / 266

页数：3

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