The state of hepatitis B and C in Europe: report from the hepatitis B and C summit conference

被引:178
作者
Hatzakis, A. [1 ]
Wait, S. [2 ]
Bruix, J. [3 ]
Buti, M. [4 ,5 ]
Carballo, M. [6 ]
Cavaleri, M. [7 ]
Colombo, M. [8 ]
Delarocque-Astagneau, E. [9 ,10 ]
Dusheiko, G. [11 ]
Esmat, G. [12 ]
Esteban, R. [4 ,5 ]
Goldberg, D. [13 ]
Gore, C. [14 ]
Lok, A. S. F. [15 ]
Manns, M. [16 ]
Marcellin, P. [17 ,18 ]
Papatheodoridis, G. [19 ]
Peterle, A.
Prati, D. [20 ,21 ]
Piorkowsky, N. [22 ]
Rizzetto, M. [23 ]
Roudot-Thoraval, F. [9 ,10 ]
Soriano, V. [24 ]
Thomas, H. C. [25 ]
Thursz, M. [25 ,26 ]
Valla, D. [27 ,28 ]
van Damme, P. [29 ]
Veldhuijzen, I. K. [30 ]
Wedemeyer, H. [31 ]
Wiessing, L. [32 ]
Zanetti, A. R. [33 ]
Janssen, H. L. A. [34 ]
机构
[1] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece
[2] SHW Hlth Ltd, London, England
[3] Univ Barcelona, Hosp Clin, IDIBAPS, CIBEREHD,Liver Unit,BCLC Grp, E-08007 Barcelona, Spain
[4] Hosp Univ Valle Hebron, Liver Unit, Barcelona, Spain
[5] CIBEREH Inst Carlos III, Barcelona, Spain
[6] Int Ctr Migrat & Hlth, Geneva, Switzerland
[7] EMA, London, England
[8] Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Div Gastroenterol 1, Milan, Italy
[9] Inst Pasteur, Inst Natl Veille Sanit, Paris, France
[10] Inst Pasteur, Emerging Dis Epidemiol Unit, Paris, France
[11] Royal Free Hosp, Ctr Hepatol, London NW3 2QG, England
[12] Cairo Univ, Dept Trop Med & Hepatol, Fac Med, Cairo, Egypt
[13] Hlth Protect Scotland, Glasgow, Lanark, Scotland
[14] World Hepatitis Alliance, London, England
[15] Univ Michigan Hlth Syst, Div Gastroenterol & Hepatol, Ann Arbor, MI USA
[16] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, D-3000 Hannover, Germany
[17] Ctr Rech Biomed Bichat Beaujon, Dept Hepatol, Clichy, France
[18] Ctr Rech Biomed Bichat Beaujon, INSERM U773 CRB3, Clichy, France
[19] Univ Athens, Sch Med, Hippokrat Gen Hosp Athens, Dept Internal Med 2, GR-11527 Athens, Greece
[20] Osped Alessandro Manzoni, Dept Transfus Med & Hematol, Lecce, Italy
[21] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Ctr Transfus Med Cellular Therapy & Cryobiol, Milan, Italy
[22] European Liver Patients Assoc, St Truiden, Belgium
[23] Univ Turin, Div Gastroenterol, Turin, Italy
[24] Hosp Carlos III, Dept Infect Dis, Madrid, Spain
[25] Univ London Imperial Coll Sci Technol & Med, Dept Gastroenterol & Hepatol, London, England
[26] EASL, London, England
[27] Univ Paris Diderot, Hop Beaujon, APHP, Serv Hepatol, Paris, France
[28] INSERM CRB3, Paris, France
[29] Univ Antwerp, Vaccine & Infect Dis Inst, Ctr Evaluat Vaccinat, Fac Med, B-2020 Antwerp, Belgium
[30] Municipal Publ Hlth Serv Rotterdam Rijnmond, Div Infect Dis Control, Rotterdam, Netherlands
[31] Leibniz Univ Hannover, Dept Gastroenterol Hepatol & Endocrinol, Hannover, Germany
[32] EMCDDA, Lisbon, Portugal
[33] Univ Milan, Dept Publ Hlth Microbiol Virol, Milan, Italy
[34] Erasmus MC Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands
关键词
Europe; hepatitis B; hepatitis C; liver cancer; policy; HEPATOCELLULAR-CARCINOMA; DISEASE PROGRESSION; COST-EFFECTIVENESS; NATURAL-HISTORY; VIRUS-INFECTION; RISK; CIRRHOSIS; VACCINE; BOOSTER; IMPACT;
D O I
10.1111/j.1365-2893.2011.01499.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Worldwide, the hepatitis B virus (HBV) and the hepatitis C virus (HCV) cause, respectively, 600 000 and 350 000 deaths each year. Viral hepatitis is the leading cause of cirrhosis and liver cancer, which in turn ranks as the third cause of cancer death worldwide. Within the WHO European region, approximately 14 million people are chronically infected with HBV, and nine million people are chronically infected with HCV. Lack of reliable epidemiological data on HBV and HCV is one of the biggest hurdles to advancing policy. Risk groups such as migrants and injecting drug users (IDU) tend to be under-represented in existing prevalence studies; thus, targeted surveillance is urgently needed to correctly estimate the burden of HBV and HCV. The most effective means of prevention against HBV is vaccination, and most European Union (EU) countries have universal vaccination programmes. For both HBV and HCV, screening of individuals who present a high risk of contracting the virus is critical given the asymptomatic, and thereby silent, nature of disease. Screening of migrants and IDUs has been shown to be effective and potentially cost-effective. There have been significant advances in the treatment of HCV and HBV in recent years, but health care professionals remain poorly aware of treatment options. Greater professional training is needed on the management of hepatitis including the treatment of liver cancer to encourage adherence to guidelines and offer patients the best possible outcomes. Viral hepatitis knows no borders. EU Member States, guided by the EU, need to work in a concerted manner to implement lasting, effective policies and programmes and make tackling viral hepatitis a public health priority.
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页码:1 / 16
页数:16
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