Hepatitis B vaccine - do we need boosters?

被引:140
作者
Banatvala, JE [1 ]
Damme, P
机构
[1] Guys Kings & St Thomas Sch Med & Dent, London SE1 7EH, England
[2] Univ Antwerp, WHO Collaborating Ctr Prevent & Control Viral Hep, B-2020 Antwerp, Belgium
关键词
booster; hepatitis B virus; immunological memory; schedule; vaccine;
D O I
10.1046/j.1365-2893.2003.00400.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
This review analyses the cumulated data from a number of long-term follow-up studies among infants, children and adults vaccinated against hepatitis B in industrialised and developing countries. Despite low or undetectable antibody responses years ater vaccination, the development of HBsAg was a rarity and, if present, only transient. Some vaccinees developed anti-HBc responses but none developed an HB carrier state or clinical manifestations of disease. Studies demonstrating anamnestic responses among those with low or undetectable anti-HBs levels following challenge with HB vaccine, together with the production of anti-HBs in circulating B-cells by spot ELISA, confirmed the presence of immune memory among vaccinees. Anamnestic anti-HBs responses all correlate close in kinetics and magnitude with proliferative T-cell responses. The accumulated data from studies assessed in this Review indicate that protection is dependent on immune memory, rather than declining anti-HBs responses and add additional weight to the European Consensus recommendations (12) that following a complete course of vaccination, booster doses are unnecessary in immunocompetent persons. If implemented, this recommendation will have considerable cost benefits world-wide.
引用
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页码:1 / 6
页数:6
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