Disseminated histoplasmosis in persons with interferon-γ receptor 1 deficiency

被引：102

作者：

Zerbe, CS

Holland, SM

机构：

[1] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA

[2] Natl Inst Allergy & Infect Dis, Lab Clin Infect Dis, NIH, Bethesda, MD USA

来源：

CLINICAL INFECTIOUS DISEASES | 2005年 / 41卷 / 04期

关键词：

D O I：

10.1086/432120

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mutations in the interferon (IFN)-gamma receptor predispose to infection with bacille Calmette-Guerin, nontuberculous mycobacteria, and Salmonella organisms. We identified a patient with recurrent disseminated Histoplasma capsulatum osteomyelitis who had an autosomal dominant form of IFN-gamma receptor 1 deficiency (i.e., a 4-bp deletion at or near base 818). IFN-gamma-mediated immunity is important in the control of histoplasmosis.

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收藏

页码：E38 / E41

页数：4

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