α,α-Diarylprolinol ethers:: New tools for functionalization of carbonyl compounds

被引：383

作者：

Mielgo, Antonia ^{[1
]}

Palomo, Claudio ^{[1
]}

机构：

[1] Univ Basque Country, Fac Quim, Dept Quim Organ 1, San Sebastian 20080, Spain

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2008年 / 3卷 / 06期

关键词：

asymmetric catalysis; enamine activation; iminium ion activation; organocatalysis; tandem reactions;

D O I：

10.1002/asia.200700417

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

alpha,alpha-Diaryl(dialkyl)prolinol ethers constitute a potent organocatalyst family which has been shown to be very general for a broad range of reactions involving enamine and iminium ion activation or a combination of both. The reactions are characterized by an efficient steric control approach and can lead to a variety of alpha-, beta-, gamma-, and alpha,beta-functionalized carbonyl compounds with excellent stereocontrol. As a full expression of their catalytic activity, these compounds are also excellent promoters of elegant cascade processes and valuable catalysts in water-compatible systems.

引用

页码：922 / 948

页数：27

共 341 条

[1] Highly diastereoselective oxy-Michael additions of enantiopure δ-lactol anions to nitroalkenes:: Asymmetric synthesis of 1,2-amino alcohols [J].