Amine-catalyzed Michael reactions of an aminoaldehyde derivative to nitroolefins

被引：31

作者：

Albertshofer, Klaus

Thayumanavan, Rajeswari

Utsumi, Naoto

Tanaka, Fujie

Barbas, Carlos F., III

机构：

[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 04期

关键词：

Michael reaction; aminoaldehyde; nitroolefin; asymmetric reactions; amine; enamine;

D O I：

10.1016/j.tetlet.2006.11.096

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Catalytic enantioselective Michael addition reactions of alpha-amino functionalized aldehydes to nitroolefins have been developed. The Michael product was obtained in tip to 98% ee, but the enantiomeric purity of the Michael product was decreased during isolation of the product. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：693 / 696

页数：4

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