Alumina-assisted reduction of carbonyl compounds with sodium borohydride in hexane

被引：21

作者：

Yakabe, S ^{[1
]}

Hirano, M ^{[1
]}

Morimoto, T ^{[1
]}

机构：

[1] Tokyo Univ Agr & Technol, Fac Technol, Dept Appl Chem, Tokyo 1848588, Japan

来源：

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE | 1998年 / 76卷 / 12期

关键词：

reduction; carbonyl compounds; sodium borohydride; alumina; alcohols;

D O I：

10.1139/v98-204

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A broad range of aliphatic, alicyclic, and aromatic ketones and aldehydes underwent smooth reduction with a combination of common, inexpensive laboratory reagents, sodium borohydride and chromatographic neutral alumina, in hexane to afford the corresponding alcohols in a selective and high-yielding manner under mild and neutral conditions. The NaBH4-based biphasic system can also successfully be used for the reduction of unsaturated substrates as well as steroidal and highly hindered ketones.

引用

页码：1916 / 1921

页数：6

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