Toll receptor-mediated Drosophila immune response requires Dif, an NF-κB factor

被引：223

作者：

Meng, XJ

Khanuja, BS

Ip, YT ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Program Mol Med, Dept Cell Biol, Worcester, MA 01605 USA

[2] Univ Massachusetts, Sch Med, Dept Biochem & Mol Biol, Worcester, MA 01605 USA

来源：

GENES & DEVELOPMENT | 1999年 / 13卷 / 07期

关键词：

immunity; Drosophila; Dif; NF-kappa B; Toll; drosomycin;

D O I：

10.1101/gad.13.7.792

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The induction of immunity genes in Drosophila has been proposed to be dependent on Dorsal, Dif, and Relish, the NF-kappa B-related factors. Hero we provide genetic evidence that Dif is required for the induction of only a subset of antimicrobial peptide genes. The results show that the presence of Dif without Dorsal is sufficient to mediate the induction of drosomycin and defensin. We also demonstrate that Dif is a downstream component of the Toll signaling pathway in activating the drosomycin expression. These results reveal that individual members of the NF-kappa B family in Drosophila have distinct roles in immunity and development.

引用

收藏

页码：792 / 797

页数：6

相关论文

共 40 条

[1] Genetic approaches to study Rel/NF-kappa B/I kappa B function in mice [J].

Attar, RM ;

Caamano, J ;

Carrasco, D ;

Iotsova, V ;

Ishikawa, H ;

Ryseck, RP ;

Weih, F ;

Bravo, R .

SEMINARS IN CANCER BIOLOGY, 1997, 8 (02) :93-101

[2]

BACUERLE PA, 1996, CELL, V87, P13

[3] Immune factor Gambif1, a new rel family member from the human malaria vector, Anopheles gambiae [J].

BarillasMury, C ;

Charlesworth, A ;

Gross, I ;

Richman, A ;

Hoffmann, JA ;

Kafatos, FC .

EMBO JOURNAL, 1996, 15 (17) :4691-4701

[4] COMPARTMENT BOUNDARIES AND THE CONTROL OF DROSOPHILA LIMB PATTERN BY HEDGEHOG PROTEIN [J].

BASLER, K ;

STRUHL, G .

NATURE, 1994, 368 (6468) :208-214

[5]

BERG CA, 1991, GENETICS, V127, P515

[6] Cloning and characterization of two Toll/interleukin-1 receptor-like genes TIL3 and TIL4: Evidence for a multi-gene receptor family in humans [J].

Chaudhary, PM ;

Ferguson, C ;

Nguyen, V ;

Nguyen, O ;

Massa, HF ;

Eby, M ;

Jasmin, A ;

Trask, BJ ;

Hood, L ;

Nelson, PS .

BLOOD, 1998, 91 (11) :4020-4027

[7] The dorsoventral signal transduction pathway and the Rel-like transcription factors in Drosophila [J].

Drier, EA ;

Steward, R .

SEMINARS IN CANCER BIOLOGY, 1997, 8 (02) :83-92

[8] Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila [J].

Dushay, MS ;

Asling, B ;

Hultmark, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (19) :10343-10347

[9] KAPPA-B-LIKE MOTIFS REGULATE THE INDUCTION OF IMMUNE GENES IN DROSOPHILA [J].

ENGSTROM, Y ;

KADALAYIL, L ;

SUN, SC ;

SAMAKOVLIS, C ;

HULTMARK, D ;

FAYE, I .

JOURNAL OF MOLECULAR BIOLOGY, 1993, 232 (02) :327-333

[10] Drosophila immunity: A comparative analysis of the Rel proteins dorsal and Dif in the induction of the genes encoding diptericin and cecropin [J].

Gross, I ;

Georgel, P ;

Kappler, C ;

Reichhart, JM ;

Hoffmann, JA .

NUCLEIC ACIDS RESEARCH, 1996, 24 (07) :1238-1245

← 1 2 3 4 →