PIP2 is a necessary cofactor for ion channel function:: How and why?

被引：505

作者：

Suh, Byung-Chang ^{[1
]}

Hille, Bertil ^{[1
]}

机构：

[1] Univ Washington, Sch Med, Dept Physiol & Biophys, Seattle, WA 98195 USA

来源：

ANNUAL REVIEW OF BIOPHYSICS | 2008年 / 37卷

关键词：

ion channel; KCNQ; lipid kinase; phospboinositides; PLC; potassium channel; TRP channel; PIP2;

D O I：

10.1146/annurev.biophys.37.032807.125859

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Phosphatidylinositol 4,5-bisphosphate (PIP2) is a minority phospholipid of the inner leaflet of plasma membranes. Many plasma membrane ion channels and ion transporters require PIP2 to function and can be turned off by signaling pathways that deplete PIP2. This review discusses the dependence of ion channels on phosphoinositides and considers possible mechanisms by which PIP2 and analogues regulate ion channel activity.

引用

页码：175 / 195

页数：21

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