Hydrophobic-at-interface regions in viral fusion protein ectodomains

被引：28

作者：

Nieva, JL

Suárez, T

机构：

[1] Univ Basque Country, Unidad Biofis, CSIC, EHU, Bilbao 48080, Spain

[2] Univ Basque Country, Dept Bioquim, Bilbao 48080, Spain

来源：

BIOSCIENCE REPORTS | 2000年 / 20卷 / 06期

关键词：

membrane fusion; viral fusion; HIV-1; gp41; influenza hemagglutinin; Sendai virus; Semliki forest virus; vesicular stomatitis virus; fusion peptide; peptide-lipid interaction; Wimley-White hydrophobicity scale;

D O I：

10.1023/A:1010458904487

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this chapter we shall describe how to apply the hydrophobicity-at-interface scale, as proposed by Wimley and White [Wimley, W. C. and White, S. H. (1996) Nature Struct. Biol. 3:842-848], to the detection of amino acid sequences of viral envelope glycoproteins putatively engaged in interactions with the target membranes. In addition, a new approach will be briefly introduced to infer the bilayer location at equilibrium of membrane-partitioning sequences. The use of these new procedures may be important in describing the molecular mechanism leading to the formation of a fusion pore by viral glycoproteins.

引用

收藏

页码：519 / 533

页数：15

相关论文

共 65 条

[21] Virus-cell and cell-cell fusion [J].

Hernandez, LD ;

Hoffman, LR ;

Wolfsberg, TG ;

White, JM .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1996, 12 :627-661

[22] An amphipathic α-helix at a membrane interface:: A structural study using a novel X-ray diffraction method [J].

Hristova, K ;

Wimley, WC ;

Mishra, VK ;

Anantharamiah, GM ;

Segrest, JP ;

White, SH .

JOURNAL OF MOLECULAR BIOLOGY, 1999, 290 (01) :99-117

[23] Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry [J].

Kilby, JM ;

Hopkins, S ;

Venetta, TM ;

DiMassimo, B ;

Cloud, GA ;

Lee, JY ;

Alldredge, L ;

Hunter, E ;

Lambert, D ;

Bolognesi, D ;

Mathews, T ;

Johnson, MR ;

Nowak, MA ;

Shaw, GM ;

Saag, MS .

NATURE MEDICINE, 1998, 4 (11) :1302-1307

[24] The mechanism for low-pH-induced clustering of phospholipid vesicles carrying the HA2 ectodomain of influenza hemagglutinin [J].

Kim, CH ;

Macosko, JC ;

Shin, YK .

BIOCHEMISTRY, 1998, 37 (01) :137-144

[25] A leucine zipper-like sequence from the cytoplasmic tail of the HIV-1 envelope glycoprotein binds and perturbs lipid bilayers [J].

Kliger, Y ;

Shai, Y .

BIOCHEMISTRY, 1997, 36 (17) :5157-5169

[26] A SIMPLE METHOD FOR DISPLAYING THE HYDROPATHIC CHARACTER OF A PROTEIN [J].

KYTE, J ;

DOOLITTLE, RF .

JOURNAL OF MOLECULAR BIOLOGY, 1982, 157 (01) :105-132

[27] MUTAGENESIS OF THE PUTATIVE FUSION DOMAIN OF THE SEMLIKI FOREST VIRUS SPIKE PROTEIN [J].

LEVYMINTZ, P ;

KIELIAN, M .

JOURNAL OF VIROLOGY, 1991, 65 (08) :4292-4300

[28] MUTATIONAL ANALYSIS OF THE VESICULAR STOMATITIS-VIRUS GLYCOPROTEIN-G FOR MEMBRANE-FUSION DOMAINS [J].

LI, Y ;

DRONE, C ;

SAT, E ;

GHOSH, HP .

JOURNAL OF VIROLOGY, 1993, 67 (07) :4070-4077

[29]

LI Y, 1994, J VIROL, V68, P2186

[30] Molecular mechanism underlying the action of a novel fusion inhibitor of influenza A virus [J].

Luo, GX ;

Torri, A ;

Harte, WE ;

Danetz, S ;

Cianci, C ;

Tiley, L ;

Day, S ;

Mullaney, D ;

Yu, KL ;

Ouellet, C ;

Dextraze, P ;

Meanwell, N ;

Colonno, R ;

Krystal, M .

JOURNAL OF VIROLOGY, 1997, 71 (05) :4062-4070

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