Synthesis of 4-aryl-1H-1,2,3-triazoles through TBAF-catalyzed [3+2] cycloaddition of 2-aryl-1-nitroethenes with TMSN3 under solvent-free conditions

被引：140

作者：

Amantini, D ^{[1
]}

Fringuelli, F ^{[1
]}

Piermatti, O ^{[1
]}

Pizzo, F ^{[1
]}

Zunino, E ^{[1
]}

Vaccaro, L ^{[1
]}

机构：

[1] Univ Perugia, CEMIN, Dipartimento Chim, I-06123 Perugia, Italy

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 16期

关键词：

D O I：

10.1021/jo0507845

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

TBAF-catalyzed [3 + 2] cycloaddition reactions of 2-aryl-1-cyano- or 2-aryl-1-carbethoxy-1-nitroethenes 1 with TMSN3 under SFC allow the corresponding 4-aryl-5-eyano- or 4-aryl-5-carbethoxy-1H-1,2,3-triazoles 2 to be prepared under mild reaction conditions and with good to excellent yields (70-90%). The proposed protocol does not require dried glassware or inert atmosphere.

引用

页码：6526 / 6529

页数：4

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