Effects of tannins and related polyphenols on methicillin-resistant Staphylococcus aureus

被引：120

作者：

Hatano, T ^{[1
]}

Kusuda, M

Inada, K

Ogawa, TO

Shiota, S

Tsuchiya, T

Yoshida, T

机构：

[1] Okayama Univ, Fac Pharmaceut Sci, Dept Pharmacognosy, Okayama 7008530, Japan

[2] Shujitsu Univ, Sch Pharm, Dept Pathogen Microbiol, Okayama 7038516, Japan

[3] Okayama Univ, Fac Pharmaceut Sci, Dept Microbiol, Okayama 7008530, Japan

来源：

PHYTOCHEMISTRY | 2005年 / 66卷 / 17期

关键词：

tea; Camellia sinensis (Theaceae); Zizyphus jujuba var. inermis (Rhamnaceae); Zanthoxylum piperitum (Rutaceae); polyphenol; tannin; proanthocyanidin; MRSA; antibiotic resistance; antibacterial;

D O I：

10.1016/j.phytochem.2005.01.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Methicillin-resistant Staphylococcus aureus (MRSA) often acquires multi-drug resistance and is involved in many cases of disease in hospitals. We investigated natural substances directly effective against MRSA or that influence antibiotic resistance. Aloe-emodin, an anthraquinone, and several licorice flavonoids showed potent antibacterial effects against MRSA. Like some hydrolysable tannins (corilagin and tellimagrandin 1) and a tea polyphenol [(-)-epicatechin gallate], the licorice flavonoid licoricidin also restored the effects of oxacillin, a beta-lactam antibiotic against MRSA. Further study revealed that theasinensin A, a polyphenol formed from (-)-pigallocatechin gallate, proanthocyanidins obtained from fruits of Zizyphus jujuba var. inermis, and polymeric proanthocyanidins from fruit peels of Zanthoxylum piperitum also suppressed the antibiotic resistance of MRSA. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2047 / 2055

页数：9

共 23 条

[1] Multiple conformations of the proline-rich protein/epigallocatechin gallate complex determined by time-averaged nuclear Overhauser effects [J].