A ''one pot'' synthesis of polysubstituted pyridines from metallated alkylphosphonates, nitriles and alpha,beta-unsaturated ketones.

被引：63

作者：

Palacios, F

deRetana, AMO

Oyarzabal, J

机构：

[1] Departamento de Quimica Organica, Facultad de Farmacia, Universidad del País Vasco, 01080 Vitoria

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 26期

关键词：

D O I：

10.1016/0040-4039(96)00850-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient synthesis of polysubstituted pyridines is described. The key step is based on the regioselective addition of lithiated beta-enaminophosphonates 5 to unsaturated carbonyl compounds 3. Pyridines 1 can also be obtained in ''one pot'' reaction from phosphonates 6 when these compounds are metallated followed by addition of nitriles and unsaturated carbonyl compounds. Copyright (C) 1996 Elsevier Science Ltd

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页码：4577 / 4580

页数：4

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