Education modifies the association of amyloid but not tangles with cognitive function

被引：92

作者：

Bennett, DA

Schneider, JA

Wilson, RS

Bienias, JL

Arnold, SE

机构：

[1] Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA

[2] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA

[3] Rush Univ, Med Ctr, Rush Inst Healthy Aging, Chicago, IL 60612 USA

[4] Rush Univ, Med Ctr, Dept Internal Med, Chicago, IL 60612 USA

[5] Univ Penn, Ctr Neurobiol & Behav, Philadelphia, PA 19104 USA

来源：

NEUROLOGY | 2005年 / 65卷 / 06期

关键词：

D O I：

10.1212/01.wnl.0000176286.17192.69

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors quantified amyloid and tau tangles in Religious Orders Study participants. In separate analyses, amyloid and tangles were related to level of cognition. When terms for education's interaction with amyloid and tangles were added, education dampened the association of amyloid with level of cognition (p = 0.02) but not the association of neurofibrillary tangles with level of cognition, suggesting that education is related to factors that reduce the effect of amyloid on cognition.

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页码：953 / 955

页数：3

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