A review of approaches to the analysis of 3-nitrotyrosine

被引：103

作者：

Duncan, MW ^{[1
]}

机构：

[1] Univ Colorado, Hlth Sci Ctr, Biochem Mass Spect Facil, Denver, CO 80262 USA

来源：

AMINO ACIDS | 2003年 / 25卷 / 3-4期

关键词：

3-nitrotyrosine; trace analysis; artifactual formation; assay validation; mass spectrometry;

D O I：

10.1007/s00726-003-0022-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Our understanding of in vivo tyrosine nitration has been confounded by problems associated with the analytical approaches that have been employed to quantify 3-nitroyrosine (3-NT). Trace analysis is a demanding task under the best of circumstances, but 3-NT offers some special concerns. This review examines some of these concerns and discusses approaches to ensuring that carefully validated analytical data are generated.

引用

页码：351 / 361

页数：11

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