Photoreceptor Signaling: Supporting Vision across a Wide Range of Light Intensities

被引：150

作者：

Arshavsky, Vadim Y. ^{[1
,2
]}

Burns, Marie E. ^{[3
,4
]}

机构：

[1] Duke Univ, Dept Ophthalmol, Durham, NC 27710 USA

[2] Duke Univ, Dept Pharmacol, Durham, NC 27710 USA

[3] Univ Calif Davis, Dept Ophthalmol & Visual Sci, Davis, CA 95618 USA

[4] Univ Calif Davis, Dept Cell Biol & Human Anat, Davis, CA 95618 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2012年 / 287卷 / 03期

基金：

美国国家卫生研究院;

关键词：

MULTIPLE PHOSPHORYLATION SITES; INTACT CONE PHOTORECEPTORS; GTPASE-ACTIVATING COMPLEX; ROD-PHOTORECEPTORS; GUANYLYL CYCLASE; RETINAL RODS; MOUSE RODS; VERTEBRATE PHOTORECEPTORS; TRANSDUCIN TRANSLOCATION; DRIVEN TRANSLOCATION;

D O I：

10.1074/jbc.R111.305243

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

For decades, photoreceptors have been an outstanding model system for elucidating basic principles in sensory transduction and biochemistry and for understanding many facets of neuronal cell biology. In recent years, new knowledge of the kinetics of signaling and the large-scale movements of proteins underlying signaling has led to a deeper appreciation of the photoreceptor's unique challenge in mediating the first steps in vision over a wide range of light intensities.

引用

页码：1620 / 1626

页数：7

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