Postmenopausal osteoporosis as a failure of bone's adaptation to functional loading: A hypothesis

被引:169
作者
Lanyon, L
Skerry, T
机构
[1] Univ London Royal Vet Coll, Dept Vet Basic Sci, London NW1 0TU, England
[2] Univ York, Dept Biol, York YO1 5DD, N Yorkshire, England
基金
爱尔兰科学基金会;
关键词
osteoporosis; adaptation; strain; estrogen receptor;
D O I
10.1359/jbmr.2001.16.11.1937
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
There is substantial evidence that bones' ability to withstand functional loading without damage depends on the processes of bone modeling and remodeling, which are responsible for establishing and maintaining bone architecture, being influenced by a feedback mechanism related to the control of functional strains. It is probably useful to consider the diminished ability to maintain bone strength in postmenopausal osteoporosis as a failure of this mechanism. Acceptance of this approach would not only increase understanding of the etiology of Postmenopausal osteoporosis but also significantly influence the ways in which it is investigated and treated. This would not mean that the many other factors affecting bone mass and bone cell activity will be ignored, but rather these factors will be put in perspective. Research to prevent or treat osteoporosis could be directed usefully to understanding how osteoblasts, lining cells, and osteocytes respond to mechanically derived information and how these responses are converted into stimuli controlling structurally appropriate modeling and remodeling. Evidence suggesting that early strain-related responses of bone cells in males and females involve the estrogen receptor (ER) could explain decreased effectiveness of this pathway when ER levels are low.
引用
收藏
页码:1937 / 1947
页数:11
相关论文
共 153 条
[51]   Intracellular Ca2+ stores and extracellular Ca2+ are required in the real-time Ca2+ response of bone cells experiencing fluid flow [J].
Hung, CT ;
Allen, FD ;
Pollack, SR ;
Brighton, CT .
JOURNAL OF BIOMECHANICS, 1996, 29 (11) :1411-1417
[52]   Differential effect of steady versus oscillating flow on bone cells [J].
Jacobs, CR ;
Yellowley, CE ;
Davis, BR ;
Zhou, Z ;
Cimbala, JM ;
Donahue, HJ .
JOURNAL OF BIOMECHANICS, 1998, 31 (11) :969-976
[53]   REVERSIBILITY OF NONTRAUMATIC DISUSE OSTEOPOROSIS DURING ITS ACTIVE PHASE [J].
JAWORSKI, ZFG ;
UHTHOFF, HK .
BONE, 1986, 7 (06) :431-439
[54]  
Jessop HL, 2000, J BONE MINER RES, V15, pS382
[55]   Mechanical stress induces COX-2 mRNA expression in bone cells from elderly women [J].
Joldersma, M ;
Burger, EH ;
Semeins, CM ;
Klein-Nulend, J .
JOURNAL OF BIOMECHANICS, 2000, 33 (01) :53-61
[56]   HUMERAL HYPERTROPHY IN RESPONSE TO EXERCISE [J].
JONES, HH ;
PRIEST, JD ;
HAYES, WC ;
TICHENOR, CC ;
NAGEL, DA .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1977, 59 (02) :204-208
[57]   THE OVARIECTOMIZED RAT MODEL OF POSTMENOPAUSAL BONE LOSS [J].
KALU, DN .
BONE AND MINERAL, 1991, 15 (03) :175-191
[58]  
KANDERS B, 1988, J BONE MINER RES, V3, P145
[59]   EFFECT OF STARTING AGE OF PHYSICAL-ACTIVITY ON BONE MASS IN THE DOMINANT ARM OF TENNIS AND SQUASH PLAYERS [J].
KANNUS, P ;
HAAPASALO, H ;
SANKELO, M ;
SIEVANEN, H ;
PASANEN, M ;
HEINONEN, A ;
OJA, P ;
VUORI, I .
ANNALS OF INTERNAL MEDICINE, 1995, 123 (01) :27-31
[60]   THE SITE-SPECIFIC EFFECTS OF LONG-TERM UNILATERAL ACTIVITY ON BONE-MINERAL DENSITY AND CONTENT [J].
KANNUS, P ;
HAAPASALO, H ;
SIEVANEN, H ;
OJA, P ;
VUORI, I .
BONE, 1994, 15 (03) :279-284