Hydrogen peroxide-mediated killing of Caenorhabditis elegans:: a common feature of different streptococcal species

被引：40

作者：

Bolm, M

Jansen, WTM

Schnabel, R

Chhatwal, GS

机构：

[1] GBF, Dept Microbial Pathogenesis & Vaccine Res, German Res Ctr Biotechnol, D-38124 Braunschweig, Germany

[2] Univ Utrecht, Med Ctr, NL-3584 CX Utrecht, Netherlands

[3] Tech Univ Braunschweig, Genet Inst, D-38106 Braunschweig, Germany

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 02期

关键词：

D O I：

10.1128/IAI.72.2.1192-1194.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recently, we reported that Streptococcus pyogenes kills Caenorhabditis elegans by the use of hydrogen peroxide (H2O2). Here we show that diverse streptococcal species cause death of C elegans larvae in proportion to the level of H2O2 produced. H2O2 may mask the effects of other pathogenicity factors of catalase-negative bacteria in the C. elegans infection model.

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页码：1192 / 1194

页数：3

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