Globin chain synthesis analysis by high performance liquid chromatography in the screening of thalassemia syndromes

被引：7

作者：

Galanello, R ^{[1
]}

Satta, S

Pirroni, MG

Travi, M

Maccioni, L

机构：

[1] Univ Cagliari, Ist Clin & Biol Eta Evolut, Osped Reg Microcitemie, I-09100 Cagliari, Italy

[2] Ist Clin Perfez, Milan, Italy

来源：

HEMOGLOBIN | 1998年 / 22卷 / 5-6期

关键词：

D O I：

10.3109/03630269809071547

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We applied reversed phase high performance liquid chromatography for globin chain synthesis analysis in screening for beta-thalassemia. The alpha/non-alpha-globin chain synthesis ratios have been determined in alpha-, beta-, and delta beta-thalassemia carriers using the classical carboxymethyl cellulose chromatography as the reference method. Reversed phase high performance liquid chromatography is fast, accurate, and reproducible, and may be a suitable alternative for the traditional carboxymethyl cellulose chromatography.

引用

页码：501 / 508

页数：8