Modelling glandular epithelial cancers in three-dimensional cultures

被引：824

作者：

Debnath, J

Brugge, JS

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

[2] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 09期

关键词：

D O I：

10.1038/nrc1695

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Little is known about how the genotypic and molecular abnormalities associated with epithelial cancers actually contribute to the histological phenotypes observed in tumours in vivo. 3D epithelial culture systems are a valuable tool for modelling cancer genes and pathways in a structurally appropriate context. Here, we review the important features of epithelial structures grown in 3D basement membrane cultures, and how such models have been used to investigate the mechanisms associated with tumour initiation and progression.

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页码：675 / 688

页数：14

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