Modelling glandular epithelial cancers in three-dimensional cultures

被引：824

作者：

Debnath, J

Brugge, JS

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

[2] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 09期

关键词：

D O I：

10.1038/nrc1695

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Little is known about how the genotypic and molecular abnormalities associated with epithelial cancers actually contribute to the histological phenotypes observed in tumours in vivo. 3D epithelial culture systems are a valuable tool for modelling cancer genes and pathways in a structurally appropriate context. Here, we review the important features of epithelial structures grown in 3D basement membrane cultures, and how such models have been used to investigate the mechanisms associated with tumour initiation and progression.

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页码：675 / 688

页数：14

相关论文

共 148 条

[91] Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase [J].

Nakagawa, S ;

Huibregtse, JM .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (21) :8244-8253

[92] BILIARY GLYCOPROTEIN, A POTENTIAL HUMAN CELL-ADHESION MOLECULE, IS DOWN-REGULATED IN COLORECTAL CARCINOMAS [J].

NEUMAIER, M ;

PAULULAT, S ;

CHAN, A ;

MATTHAES, P ;

WAGENER, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (22) :10744-10748

[93] IN-VITRO KARYOTYPE EVOLUTION AND CYTOGENETIC INSTABILITY IN THE NONTUMORIGENIC HUMAN BREAST EPITHELIAL-CELL LINE HMT-3522 [J].

NIELSEN, KV ;

MADSEN, MW ;

BRIAND, P .

CANCER GENETICS AND CYTOGENETICS, 1994, 78 (02) :189-199

[94] Reconstitution of mammary gland development in vitro: Requirement of c-met and c-erbB2 signaling for branching and alveolar morphogenesis [J].

Niemann, C ;

Brinkmann, V ;

Spitzer, E ;

Hartmann, G ;

Sachs, M ;

Naundorf, H ;

Birchmeier, W .

JOURNAL OF CELL BIOLOGY, 1998, 143 (02) :533-545

[95] Tumor cell locomotion: differential dynamics of spontaneous and induced migration in a 3D collagen matrix [J].

Niggemann, B ;

Drell, TL ;

Joseph, J ;

Weidt, C ;

Lang, K ;

Zaenker, KS ;

Entschladen, F .

EXPERIMENTAL CELL RESEARCH, 2004, 298 (01) :178-187

[96] ERK and MMPs sequentially regulate distinct stages of epithelial tubule development [J].

O'Brien, LE ;

Tang, K ;

Kats, ES ;

Schutz-Geschwender, A ;

Lipschutz, JH ;

Mostov, KE .

DEVELOPMENTAL CELL, 2004, 7 (01) :21-32

[97] Opinion - Building epithelial architecture: insights from three-dimensional culture models [J].

O'Brien, LE ;

Zegers, MMP ;

Mostov, KE .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (07) :531-537

[98] Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly [J].

O'Brien, LE ;

Jou, TS ;

Pollack, AL ;

Zhang, QH ;

Hansen, SH ;

Yurchenco, P ;

Mostov, KE .

NATURE CELL BIOLOGY, 2001, 3 (09) :831-838

[99] TGF-beta 1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells [J].

Oft, M ;

Peli, J ;

Rudaz, C ;

Schwarz, H ;

Beug, H ;

Reichmann, E .

GENES & DEVELOPMENT, 1996, 10 (19) :2462-2477

[100]

Ojakian GK, 1997, J CELL SCI, V110, P2781

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