Biotransformation of citrus aromatics nootkatone and valencene by microorganisms

被引：45

作者：

Furusawa, M

Hashimoto, T

Noma, Y

Asakawa, Y

机构：

[1] Tokushima Bunri Univ, Fac Pharmaceut Sci, Tokushima 7708514, Japan

[2] Tokushima Bunri Univ, Fac Human Life Sci, Tokushima 7708514, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2005年 / 53卷 / 11期

关键词：

nootkatone; valencene; biotransformation; Aspergillus niger; Fusurium cultnorum; Botryosphaeria dothidea;

D O I：

10.1248/cpb.53.1423

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Biotransformations of the sesquiterpene ketone nootkatone (1) from the crude drug Alpiniae Fructus and grapefruit oil, and the sesquiterpene hydrocarbon valencene (2) from Valencia orange oil were carried out with microorganisms such as Aspergillus niger, Botryosphaeria dothidea, and Fusarium culmorum to afford structurally interesting metabolites. Their stereostructures were established by a combination of high-resolution NMR spectral and X-ray crystallographic analysis and chemical reaction. Metabolic pathways of compounds 1 and 2 by A. niger are proposed.

引用

页码：1423 / 1429

页数：7

共 19 条

[1] CIRCULAR DICHROISM OF -] PI] BAND OF CYCLIC THIONOCARBONATES .1. RELATIONSHIP BETWEEN MAGNITUDE AND SIGN OF COTTON EFFECT, AND CHIRALITY OF 5-MEMBERED THIONOCARBONATE RING [J].