Photosensitizer delivery for photodynamic therapy of choroidal neovascularization

被引：59

作者：

Renno, RZ ^{[1
]}

Miller, JW ^{[1
]}

机构：

[1] Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Angiogenesis Lab,Retina Serv, Boston, MA 02115 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2001年 / 52卷 / 01期

关键词：

photosensitizer delivery; photosensitizer circulation; liposomal formulation; delivery vehicles; antibody-targeted photolysis; photodynamic therapy; choroidal neovascularization; age-related macular degeneration; verteporfin; benzoporphyrin derivative; Lu-Tex; motexatin lutetium; tin ethyl purpurin;

D O I：

10.1016/S0169-409X(01)00195-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present review examines the importance of improving photosensitizer delivery for choroidal neovascularization (CNV) in light of the clinical impact of photodynamic therapy (PDT) for CNV An overview of the classes of available photosensitizers is provided and the properties governing photosensitizer uptake and circulation in serum are discussed. Current delivery systems, for example liposomal formulations as well as the use of the promising strategy of antibody targeted delivery as a strategy to improve PDT selectivity and efficiency for CNV treatment are described. A summary of the work using Verteporfin, tin ethyl purpurin and Lu-Tex - photosensitizers currently in clinical trials for CNV - is given. (C) 2001 Elsevier Science B V. All rights rc;served.

引用

页码：63 / 78

页数：16

共 92 条

[1] LONG-CIRCULATING (STERICALLY STABILIZED) LIPOSOMES FOR TARGETED DRUG-DELIVERY [J].