Serological response and persistence in schoolchildren with high baseline seropositive rate after receiving 2009 pandemic influenza A(H1N1) vaccine

被引：9

作者：

Chao, Day-Yu ^{[1
]}

Cheng, Kuang-Fu ^{[2
]}

Hsieh, Ying-Hen ^{[3
]}

Li, Tsai-Chung ^{[2
,3
]}

Wu, Trong-Neng ^{[3
,4
]}

Chen, Chiu-Ying ^{[4
]}

Tsai, Chen-An ^{[2
,3
]}

Chen, Jin-Hwa ^{[2
,3
]}

Chiu, Hsien-Tsai ^{[2
,4
]}

Lu, Jang-Jih ^{[5
,6
]}

Su, Mei-Chi ^{[6
]}

Liao, Yu-Hsin ^{[1
]}

机构：

[1] Natl Chung Hsing Univ, Grad Inst Microbiol & Publ Hlth, Coll Vet Med, Taichung 401, Taiwan

[2] China Med Univ, Ctr Biostat, Taichung, Taiwan

[3] China Med Univ, Dept Publ Hlth, Taichung, Taiwan

[4] China Med Univ, Grad Inst Biostat, Taichung, Taiwan

[5] China Med Univ, Grad Inst Clin Med Sci, Taichung, Taiwan

[6] China Med Univ Hosp, Dept Lab Med, Taichung, Taiwan

来源：

VACCINE | 2011年 / 29卷 / 04期

关键词：

Pandemic influenza; 2009; pH1N1; Vaccine; Serology; Immune response; Schoolchildren; A H1N1; SEASONAL INFLUENZA; IMMUNOGENICITY; CHILDREN; VIRUS; ANTIBODY; INFANTS; SAFETY;

D O I：

10.1016/j.vaccine.2010.11.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The serological response of the current 2009 H1N1 pandemic influenza monovalent vaccine in children exhibiting high baseline seropositive rate was evaluated though a community-based household study. Seroprotection rate of >90% and seroconversion rate of >50% were observed in children one month after receiving the pandemic vaccine. Among children with low baseline antibody titer, a significant lower seroconversion rate (55%) was observed in children who received seasonal trivalent inactivated vaccine (TIV) prior to pandemic vaccine, when compared with those receiving the pandemic vaccine only (86%). Persistence of antibody against the pandemic influenza virus was observed 6 months after vaccination in >80% of children presenting seroprotective antibody levels. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：617 / 623

页数：7

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