The cellular neurobiology of depression

被引：875

作者：

Manji, HK ^{[1
]}

Drevets, WC

Charney, DS

机构：

[1] NIMH, Mol Pathophysiol Lab, Bethesda, MD 20892 USA

[2] NIMH, Sect Neuroimaging, Bethesda, MD 20892 USA

[3] NIMH, Mood & Anxiety Disorders Res Program, Bethesda, MD 20892 USA

来源：

NATURE MEDICINE | 2001年 / 7卷 / 05期

关键词：

D O I：

10.1038/87865

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Major depressive disorders, long considered to be of neurochemical origin, have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways may hold promise as new therapeutics for depression.

引用

收藏

页码：541 / 547

页数：7

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