The cellular neurobiology of depression

被引：872

作者：

Manji, HK ^{[1
]}

Drevets, WC

Charney, DS

机构：

[1] NIMH, Mol Pathophysiol Lab, Bethesda, MD 20892 USA

[2] NIMH, Sect Neuroimaging, Bethesda, MD 20892 USA

[3] NIMH, Mood & Anxiety Disorders Res Program, Bethesda, MD 20892 USA

来源：

NATURE MEDICINE | 2001年 / 7卷 / 05期

关键词：

D O I：

10.1038/87865

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Major depressive disorders, long considered to be of neurochemical origin, have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways may hold promise as new therapeutics for depression.

引用

收藏

页码：541 / 547

页数：7

相关论文

共 73 条

[61] Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders [J].

Sapolsky, RM .

ARCHIVES OF GENERAL PSYCHIATRY, 2000, 57 (10) :925-935

[62]

Schatzberg Alan F., 1995, P911

[63] Association between depression and mortality in older adults - The Cardiovascular Health Study [J].

Schulz, R ;

Beach, SR ;

Ives, DG ;

Martire, LM ;

Ariyo, AA ;

Kop, WJ .

ARCHIVES OF INTERNAL MEDICINE, 2000, 160 (12) :1761-1768

[64] Psychosomatic aspects of Cushing's disease [J].

Sonino, N ;

Fava, GA .

PSYCHOTHERAPY AND PSYCHOSOMATICS, 1998, 67 (03) :140-146

[65] Decrease in cortisol reverses human hippocampal atrophy following treatment of Cushing's disease [J].

Starkman, MN ;

Giodani, B ;

Gebarski, SS ;

Berent, S ;

Schork, MA ;

Schteingart, DE .

BIOLOGICAL PSYCHIATRY, 1999, 46 (12) :1595-1602

[66]

Starkstein, 1996, Semin Clin Neuropsychiatry, V1, P272

[67] AFFECTIVE-DISORDERS AND CEREBRAL VASCULAR-DISEASE [J].

STARKSTEIN, SE ;

ROBINSON, RG .

BRITISH JOURNAL OF PSYCHIATRY, 1989, 154 :170-182

[68] Magnetic resonance imaging signal hypointensity and iron content of putamen nuclei in elderly depressed patients [J].

Steffens, DC ;

Tupler, LA ;

Ranga, K ;

Krishnan, R .

PSYCHIATRY RESEARCH-NEUROIMAGING, 1998, 83 (02) :95-103

[69] The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory [J].

Sweatt, JD .

JOURNAL OF NEUROCHEMISTRY, 2001, 76 (01) :1-10

[70] N-ACETYLASPARTATE IN NEUROPSYCHIATRIC DISORDERS [J].

TSAI, GC ;

COYLE, JT .

PROGRESS IN NEUROBIOLOGY, 1995, 46 (05) :531-540

← 1 2 3 4 5 6 7 8 →