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ProTherm, version 4.0: thermodynamic database for proteins and mutants

被引：289
作者：
Bava, KA
Gromiha, MM
Uedaira, H
Kitajima, K
Sarai, A
机构：
[1] Kyushu Inst Technol, Dept Biochem Engn & Sci, Iizuka, Fukuoka 8208502, Japan
[2] Natl Inst Adv Ind Sci & Technol, CBRC, Koto Ku, Tokyo 1350064, Japan
来源：
NUCLEIC ACIDS RESEARCH | 2004年 / 32卷
关键词：
D O I：
10.1093/nar/gkh082
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Release 4.0 of ProTherm, thermodynamic database for proteins and mutants, contains similar to14 500 numerical data (similar to450% of the first version) of several thermodynamic parameters along with experimental methods and conditions, and structural, functional and literature information. The sequence and structural information of proteins is connected with thermodynamic data through links between entries in Protein Data Bank, Protein Information Resource and SWISS-PROT and the data in ProTherm. We have separated the Gibbs free energy change obtained at extrapolated temperature from the data on denaturation temperature measured by the thermal denaturation method. We have added the statistics of amino acid replacements and links to homologous structures to each protein. Further, we have improved the search and display options to enhance search capability through the web interface. ProTherm is freely available at http://gibk26. bse.kyutech.ac.jp/jouhou/Protherm/protherm.htmi.
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页码：D120 / D121
页数：2
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