CGP 36 742, an orally active GABA(B) receptor antagonist, facilitates memory in a social recognition test in rats

被引：31

作者：

Mondadori, C ^{[1
]}

Moebius, HJ ^{[1
]}

Zingg, M ^{[1
]}

机构：

[1] CIBA GEIGY AG,PHARMACEUT RES DEPT,CH-4002 BASEL,SWITZERLAND

来源：

BEHAVIOURAL BRAIN RESEARCH | 1996年 / 77卷 / 1-2期

关键词：

CGP; 36; 742; GABA(B); memory; social recognition; rat;

D O I：

10.1016/0166-4328(95)00226-X

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

CGP 36 742, an orally active GABA(B) receptor antagonist, improves the retention performance of rats in a social recognition test. This effect is detectable over a very wide range of doses (0.03 to 300 mg/kg, p.o.). Considering its binding (32 mu mol affinity for the GABA(B) site) the surprisingly potent activity of CGP 36 742 makes it appear quite possible that the effect is mediated by an as yet unknown receptor subtype.

引用

页码：227 / 229

页数：3

共 12 条

[1] INCREASED ACETYLCHOLINE AND QUISQUALATE RESPONSIVENESS AFTER BLOCKADE OF GABA (B)-RECEPTORS [J].

ANDRE, P ;

FERRAT, T ;

STEINMAN, M ;

OLPE, HR .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 218 (01) :137-143

[2]

BERNASCONI R, 1992, PHARM COMMUN, V2, P28

[3] GABAB RECEPTORS AND THEIR SIGNIFICANCE IN MAMMALIAN PHARMACOLOGY [J].

BOWERY, N .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1989, 10 (10) :401-407

[4]

CARLETTI R, 1993, BRIT J PHARMACOL, V109, pP74

[5] OLFACTORY RECOGNITION OF CONSPECIFICS BY DOMESTIC NORWAY RATS [J].

CARR, WJ ;

YEE, L ;

GABLE, D ;

MARASCO, E .

JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1976, 90 (09) :821-828

[6] FACILITATION OF SOCIAL-LEARNING BY TREATMENT WITH AN NMDA RECEPTOR ANTAGONIST [J].

LEDERER, R ;

RADEKE, E ;

MONDADORI, C .

BEHAVIORAL AND NEURAL BIOLOGY, 1993, 60 (03) :220-224

[7]

MONCADORI C, 1994, P NATL ACAD SCI USA, V91, P2041

[8] The GABA(B) receptor antagonist CGP 36 742 and the nootropic oxiracetam facilitate the formation of long-term memory [J].

Mondadori, C ;

Mobius, HJ ;

Borkowski, J .

BEHAVIOURAL BRAIN RESEARCH, 1996, 77 (1-2) :223-225

[9] CGP-36742 - THE 1ST ORALLY-ACTIVE GABA(B)-BLOCKER IMPROVES THE COGNITIVE PERFORMANCE OF MICE, RATS, AND RHESUS-MONKEYS [J].

MONDADORI, C ;

JAEKEL, J ;

PREISWERK, G .

BEHAVIORAL AND NEURAL BIOLOGY, 1993, 60 (01) :62-68

[10]

STEULET AF, IN PRESS BIOCH PHARM

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