Effects of age-related shifts in cellular function and local microenvironment upon the innate immune response to implants

被引:39
作者
Brown, Bryan N. [1 ,2 ,3 ]
Haschak, Martin J. [1 ,2 ]
Lopresti, Samuel T. [1 ,2 ]
Stahl, Elizabeth C. [1 ,4 ]
机构
[1] Univ Pittsburgh, McGowan Inst Regenerat Med, 450 Technol Dr,Suite 300, Pittsburgh, PA 15219 USA
[2] Univ Pittsburgh, Swanson Sch Engn, Dept Bioengn, 3700 OHara St, Pittsburgh, PA 15260 USA
[3] Univ Pittsburgh, Sch Med, Dept Obstet Gynecol & Reprod Sci, 300 Halket St, Pittsburgh, PA 15213 USA
[4] Univ Pittsburgh, Sch Med, Dept Pathol, 200 Lothrop St, Pittsburgh, PA 15261 USA
基金
美国国家卫生研究院;
关键词
Macrophage; Polarization; Host response; Aging; Implant; GLYCATION END-PRODUCTS; T-LYMPHOCYTE SUBPOPULATIONS; CALCIUM-ION BINDING; SOURCE ANIMAL AGE; MACROPHAGE PHENOTYPE; EXTRACELLULAR-MATRIX; HOST RESPONSE; SURFACE-CHEMISTRY; UP-REGULATION; IN-VIVO;
D O I
10.1016/j.smim.2017.05.001
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
071005 [微生物学]; 100108 [医学免疫学];
摘要
The host macrophage response is now well recognized as a predictor of the success or failure of biomaterial implants following placement. More specifically, shifts from an "M1" pro-inflammatory towards a more "M2- like" anti-inflammatory macrophage polarization profile have been shown to result in enhanced material integration and/or tissue regeneration downstream. As a result, a number of biomaterials-based approaches to controlling macrophage polarization have been developed. However, the ability to promote such activity is predicated upon an in-depth, context-dependent understanding of the host response to biomaterials. Recent work has shown the impacts of both tissue location and tissue status (i.e. underlying pathology) upon the host innate immune response to implants, representing a departure from a focus upon implant material composition and form. Thus, the ideas of "biocompatibility," the host macrophage reaction, and ideal material requirements and modification strategies may need to be revisited on a patient, tissue, and disease basis. Immunosenescence, dysregulation of macrophage function, and delayed resolution of immune responses in aged individuals have all been demonstrated, suggesting that the host response to biomaterials in aged individuals should differ from that in younger individuals. However, despite the increasing usage of implantable medical devices in aged patients, few studies examining the effects of aging upon the host response to biomaterials and the implications of this response for long-term integration and function have been performed. The objective of the present manuscript is to review the putative effects of aging upon the host response to implanted materials and to advance the hypothesis that age-related changes in the local microenvrionement, with emphasis on the extracellular matrix, play a previously unrecognized role in determining the host response to implants.
引用
收藏
页码:24 / 32
页数:9
相关论文
共 148 条
[1]
Nitric oxide and superoxide anion production decrease with age in resident and activated rat peritoneal macrophages [J].
Alvarez, E ;
Machado, A ;
Sobrino, F ;
Maria, CS .
CELLULAR IMMUNOLOGY, 1996, 169 (01) :152-155
[2]
Alvarez MM, 2016, J CONTROL RELEASE
[3]
The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis [J].
Amit, Ido ;
Winter, Deborah R. ;
Jung, Steffen .
NATURE IMMUNOLOGY, 2016, 17 (01) :18-25
[4]
Inflammatory response to implants [J].
Anderson, J.M. .
ASAIO Transactions, 1988, 34 (02) :101-107
[5]
Foreign body reaction to biomaterials [J].
Anderson, James M. ;
Rodriguez, Analiz ;
Chang, David T. .
SEMINARS IN IMMUNOLOGY, 2008, 20 (02) :86-100
[6]
Ashcroft GS, 1998, LAB INVEST, V78, P47
[7]
Immunosenescence: emerging challenges for an ageing population [J].
Aw, Danielle ;
Silva, Alberto B. ;
Palmer, Donald B. .
IMMUNOLOGY, 2007, 120 (04) :435-446
[8]
Cross-linking influences the impact of quantitative changes in myocardial collagen on cardiac stiffness and remodelling in hypertension in rats [J].
Badenhorst, D ;
Maseko, M ;
Tsotetsi, OJ ;
Naidoo, A ;
Brooksbank, R ;
Norton, GR ;
Woodiwiss, AJ .
CARDIOVASCULAR RESEARCH, 2003, 57 (03) :632-641
[9]
The narrowing of the CD8 T cell repertoire in old age [J].
Blackman, Marcia A. ;
Woodland, David L. .
CURRENT OPINION IN IMMUNOLOGY, 2011, 23 (04) :537-542
[10]
Surface chemistry to minimize fouling from blood-based fluids [J].
Blaszykowski, Christophe ;
Sheikh, Sonia ;
Thompson, Michael .
CHEMICAL SOCIETY REVIEWS, 2012, 41 (17) :5599-5612