Lipase-catalyzed enantioselective reaction of amines with carboxylic acids under reduced pressure in non-solvent system and in ionic liquids

被引：65

作者：

Irimescu, R ^{[1
]}

Kato, K ^{[1
]}

机构：

[1] Natl Inst Adv Ind Sci & Technol, Ceram Res Inst, Biofunct Ceram Grp, Moriyama Ku, Nagoya, Aichi 4638560, Japan

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 03期

关键词：

enzymatic amide synthesis; ionic liquids; kinetic resolution; lipase; non-solvent reaction system; primary amine;

D O I：

10.1016/j.tetlet.2003.10.210

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lipase-catalyzed enantioselective acylation of I-phenylethylamine and 2-phenyl-1-propylamine was performed by reacting the amines with carboxylic acids in a non-solvent system or in ionic liquids as reaction media. The reaction equilibrium was shifted toward amide synthesis by the removal of formed water under reduced pressure. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：523 / 525

页数：3

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