Efficient lipase-catalyzed enantioselective acylation under reduced pressure conditions in an ionic liquid solvent system

被引：68

作者：

Itoh, T ^{[1
]}

Akasaki, E

Nishimura, Y

机构：

[1] Tottori Univ, Fac Engn, Dept Mat Sci, Tottori 6808552, Japan

[2] Okayama Univ, Fac Educ, Dept Chem, Okayama 7008530, Japan

来源：

CHEMISTRY LETTERS | 2002年 / 02期

关键词：

D O I：

10.1246/cl.2002.154

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Lipase-catalyzed transesterification was demonstrated using methyl esters as acyl donors under reduced pressure in an ionic liquid ([bmim]PF6) solvent system. The transesterification of 5-phenyl-1-penten-3-ol took place smoothly under reduced pressure at 27 hPa at 40 degreesC when methyl phenylthioacetate was used as acyl donor in [bmim]PF6, and we succeeded in obtaining the corresponding acylated compound in optically pure form; this makes it possible to use lipase repeatedly because there was no drop in the reaction rate despite three repetitions of the process.

引用

页码：154 / 155

页数：2

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