ENHANCED ENANTIOSELECTIVITY OF AN ENZYMATIC-REACTION BY THE SULFUR FUNCTIONAL-GROUP - A SIMPLE PREPARATION OF OPTICALLY-ACTIVE BETA-HYDROXY NITRILES USING A LIPASE

被引:52
作者
ITOH, T
TAKAGI, Y
NISHIYAMA, S
机构
[1] Department of Chemistry, Faculty of Education, Okayama University
关键词
D O I
10.1021/jo00004a033
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The enantioselectivity of a lipase-catalyzed hydrolysis was improved by varying the acyl residue into the sulfur functional one, i.e. the beta-(phenylthio)- or beta-(methylthio)acetoxy group, from acetate or valerate to realize satisfactory resolution of beta-hydroxy nitriles using lipase P (Pseudomonas sp.).
引用
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页码:1521 / 1524
页数:4
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