A biologically active form of chromium may activate a membrane phosphotyrosine phosphatase (PTP)

被引：94

作者：

Davis, CM ^{[1
]}

Sumrall, KH ^{[1
]}

Vincent, JB ^{[1
]}

机构：

[1] UNIV ALABAMA, DEPT CHEM, TUSCALOOSA, AL 35487 USA

来源：

BIOCHEMISTRY | 1996年 / 35卷 / 39期

关键词：

D O I：

10.1021/bi960328y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chromium is essential for proper carbohydrate and lipid metabolism in mammals, although the mechanism of this action has previously proved elusive. Low-molecular-weight chromium-binding protein (LMWCr), a biologically active form of chromium in mammals, potentiates the effect of insulin on the conversion of glucose into lipid and into carbon dioxide in isolated adipocytes. Kinetics studies indicate that LMWCr isolated from bovine liver activates phosphotyrosine phosphatase (PTP) activity in adipocyte membranes while having no intrinsic phosphatase activity. This activation is directly proportional to the amount of added LMWCr. The pattern of inhibition of this activity in the presence of a number of known phosphatase inhibitors suggests the involvement of a membrane phosphotyrosine phosphatase similar to PTP1A' or PTP1B. We propose that chromium plays a biological role in the activation of a membrane phosphotyrosine phosphatase.

引用

页码：12963 / 12969

页数：7

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