Aptamer database

被引:146
作者
Lee, JF
Hesselberth, JR
Meyers, LA
Ellington, AD
机构
[1] Univ Texas, Inst Cell & Mol Biol, Dept Chem & Biochem, Austin, TX 78712 USA
[2] Univ Washington, Dept Genome Sci, Seattle, WA 98915 USA
[3] Univ Texas, Sect Integrat Biol, Austin, TX 78712 USA
关键词
D O I
10.1093/nar/gkh094
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The aptamer database is designed to contain comprehensive sequence information on aptamers and unnatural ribozymes that have been generated by in vitro selection methods. Such data are not normally collected in 'natural' sequence databases, such as GenBank. Besides serving as a storehouse of sequences that may have diagnostic or therapeutic utility, the database serves as a valuable resource for theoretical biologists who describe and explore fitness landscapes. The database is updated monthly and is publicly available at http://aptamer. icmb.utexas.edu/.
引用
收藏
页码:D95 / D100
页数:6
相关论文
共 39 条
[1]   SELECTION OF SINGLE-STRANDED-DNA MOLECULES THAT BIND AND INHIBIT HUMAN THROMBIN [J].
BOCK, LC ;
GRIFFIN, LC ;
LATHAM, JA ;
VERMAAS, EH ;
TOOLE, JJ .
NATURE, 1992, 355 (6360) :564-566
[2]  
Brody E N, 2000, J Biotechnol, V74, P5, DOI 10.1016/S1389-0352(99)00004-5
[3]  
Burgstaller P, 2002, CURR OPIN DRUG DISC, V5, P690
[4]   Statistical prediction of single-stranded regions in RNA secondary structure and application to predicting effective antisense target sites and beyond [J].
Ding, Y ;
Lawrence, CE .
NUCLEIC ACIDS RESEARCH, 2001, 29 (05) :1034-1046
[5]   The joys of in vitro selection: chemically dressing oligonucleotides to satiate protein targets [J].
Eaton, BE .
CURRENT OPINION IN CHEMICAL BIOLOGY, 1997, 1 (01) :10-16
[6]   STRUCTURALLY COMPLEX AND HIGHLY-ACTIVE RNA LIGASES DERIVED FROM RANDOM RNA SEQUENCES [J].
EKLAND, EH ;
SZOSTAK, JW ;
BARTEL, DP .
SCIENCE, 1995, 269 (5222) :364-370
[7]   INVITRO SELECTION OF RNA MOLECULES THAT BIND SPECIFIC LIGANDS [J].
ELLINGTON, AD ;
SZOSTAK, JW .
NATURE, 1990, 346 (6287) :818-822
[8]  
Famulok M, 1999, CURR TOP MICROBIOL, V243, P123
[9]   Aptamer structures from A to zeta [J].
Feigon, J ;
Dieckmann, T ;
Smith, FW .
CHEMISTRY & BIOLOGY, 1996, 3 (08) :611-617
[10]   FAST FOLDING AND COMPARISON OF RNA SECONDARY STRUCTURES [J].
HOFACKER, IL ;
FONTANA, W ;
STADLER, PF ;
BONHOEFFER, LS ;
TACKER, M ;
SCHUSTER, P .
MONATSHEFTE FUR CHEMIE, 1994, 125 (02) :167-188