Immunoexpression of cyclooxygenase-2 in primary gastric carcinomas and lymph node metastases

被引：29

作者：

Almeida, Paulo R. C. ^{[1
]}

Ferreira, Francisco V. A. ^{[2
]}

Santos, Cassio C. ^{[2
]}

Rocha-Filho, Francisco D. ^{[2
]}

Feitosa, Raul R. P.

Falcao, Esther A. A.

Cavada, Belise K.

Lima-Junior, Roberto C. P.

Ribeiro, Ronaldo A. ^{[2
]}

机构：

[1] Univ Fed Ceara, Dept Pathol & Forens Med, Fac Med, BR-60430350 Fortaleza, Ceara, Brazil

[2] Hosp Canc, Canc Inst Ceara, BR-60430350 Fortaleza, Ceara, Brazil

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2012年 / 18卷 / 08期

关键词：

Cyclooxygenase-2; Gastric carcinoma; Immunoexpression; Lymph node metastases; Tissue microarray; HELICOBACTER-PYLORI INFECTION; ENDOTHELIAL GROWTH-FACTOR; FACTOR EXPRESSION; BREAST-CANCER; CARCINOGENESIS; ANGIOGENESIS; INVASION; P53; ADENOCARCINOMA; EPIDEMIOLOGY;

D O I：

10.3748/wjg.v18.i8.778

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

AIM: To evaluate immunoexpression of cyclooxygenase-2 (COX-2) in primary gastric carcinomas and respective lymph node metastases. METHODS: Immunohistochemistry to analyze COX-2 expression was performed on tissue microarray slices obtained from 36 specimens of gastrectomy and satellite lymph nodes from patients with gastric carcinoma. RESULTS: Immunostaining was seen in most cases, and COX-2 expression was higher in lymph node metastases than in corresponding primary gastric tumors of intestinal, diffuse and mixed carcinomas, with a statistically significant difference in the diffuse histotype (P = 0.0108). CONCLUSION: COX-2 innmunoexpression occurs frequently in primary gastric carcinomas, but higher expression of this enzyme is observed in lymph node metastases of the diffuse histotype. (C) 2012 Baishideng. All rights reserved.

引用

页码：778 / 784

页数：7

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