The role of quorum sensing in the in vivo virulence of Pseudomonas aeruginosa

被引：159

作者：

Rumbaugh, KP

Griswold, JA

Hamood, AN

机构：

[1] Texas Tech Univ, Hlth Sci Ctr, Dept Microbiol & Immunol, Lubbock, TX 79430 USA

[2] Texas Tech Univ, Hlth Sci Ctr, Dept Surg, Lubbock, TX 79430 USA

来源：

MICROBES AND INFECTION | 2000年 / 2卷 / 14期

关键词：

Pseudomonas aeruginosa; quorum sensing; pathogenesis;

D O I：

10.1016/S1286-4579(00)01327-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pseudomonas aeruginosa is an opportunistic pathogen that causes a wide variety of infections. The cell-density-dependent signaling mechanisms known as quorum sensing play a role in several of these infections including corneal, lung and burn wound infections. In addition, the quorum-sensing systems contribute to the ability of P. aeruginosa to form biofilms on medically important: devices. The quorum-sensing systems accomplish their effect by controling the production of different virulence factors and by manipulating the host immune response. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

收藏

页码：1721 / 1731

页数：11

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