The role of quorum sensing in the in vivo virulence of Pseudomonas aeruginosa

被引：159

作者：

Rumbaugh, KP

Griswold, JA

Hamood, AN

机构：

[1] Texas Tech Univ, Hlth Sci Ctr, Dept Microbiol & Immunol, Lubbock, TX 79430 USA

[2] Texas Tech Univ, Hlth Sci Ctr, Dept Surg, Lubbock, TX 79430 USA

来源：

MICROBES AND INFECTION | 2000年 / 2卷 / 14期

关键词：

Pseudomonas aeruginosa; quorum sensing; pathogenesis;

D O I：

10.1016/S1286-4579(00)01327-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pseudomonas aeruginosa is an opportunistic pathogen that causes a wide variety of infections. The cell-density-dependent signaling mechanisms known as quorum sensing play a role in several of these infections including corneal, lung and burn wound infections. In addition, the quorum-sensing systems contribute to the ability of P. aeruginosa to form biofilms on medically important: devices. The quorum-sensing systems accomplish their effect by controling the production of different virulence factors and by manipulating the host immune response. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

收藏

页码：1721 / 1731

页数：11

相关论文

共 67 条

[11]

DUNNY GM, 1999, CELL CELL SIGNALING

[12] Quorum sensing: A novel target for anti-infective therapy [J].

Finch, RG ;

Pritchard, DI ;

Bycroft, BW ;

Williams, P ;

Stewart, GSAB .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1998, 42 (05) :569-571

[13] ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury [J].

FinckBarbancon, V ;

Goranson, J ;

Zhu, L ;

Sawa, T ;

WienerKronish, JP ;

Fleiszig, SMJ ;

Wu, C ;

MendeMueller, L ;

Frank, DW .

MOLECULAR MICROBIOLOGY, 1997, 25 (03) :547-557

[14] Self perception in bacteria: quorum sensing with acylated homoserine lactones [J].

Fuqua, C ;

Greenberg, EP .

CURRENT OPINION IN MICROBIOLOGY, 1998, 1 (02) :183-189

[15] Census and consensus in bacterial ecosystems: The LuxR-LuxI family of quorum-sensing transcriptional regulators [J].

Fuqua, C ;

Winans, SC ;

Greenberg, EP .

ANNUAL REVIEW OF MICROBIOLOGY, 1996, 50 :727-751

[16] LASR OF PSEUDOMONAS-AERUGINOSA IS A TRANSCRIPTIONAL ACTIVATOR OF THE ALKALINE PROTEASE GENE (APR) AND AN ENHANCER OF EXOTOXIN-A EXPRESSION [J].

GAMBELLO, MJ ;

KAYE, S ;

IGLEWSKI, BH .

INFECTION AND IMMUNITY, 1993, 61 (04) :1180-1184

[17] CLONING AND CHARACTERIZATION OF THE PSEUDOMONAS-AERUGINOSA LASR GENE, A TRANSCRIPTIONAL ACTIVATOR OF ELASTASE EXPRESSION [J].

GAMBELLO, MJ ;

IGLEWSKI, BH .

JOURNAL OF BACTERIOLOGY, 1991, 173 (09) :3000-3009

[18] Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of twitching motility [J].

Glessner, A ;

Smith, RS ;

Iglewski, BH ;

Robinson, JB .

JOURNAL OF BACTERIOLOGY, 1999, 181 (05) :1623-1629

[19] Intercellular communication and group behavior in bacteria [J].

Gray, KM .

TRENDS IN MICROBIOLOGY, 1997, 5 (05) :184-188

[20] Quorum sensing and the cell-cell communication dependent regulation of gene expression in pathogenic and non-pathogenic bacteria [J].

Hardman, AM ;

Stewart, GSAB ;

Williams, P .

ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 1998, 74 (04) :199-210

← 1 2 3 4 5 6 7 →