Cellular prion protein ablation impairs behavior as a function of age

被引：71

作者：

Coitinho, AS ^{[1
]}

Roesler, R

Martins, VR

Brentani, RR

Izquierdo, I

机构：

[1] Univ Fed Rio Grande do Sul, ICBS, Dept Bioquim, Ctr Memoria, Porto Alegre, RS, Brazil

[2] Ludwig Inst Canc Res, Sao Paulo, Brazil

来源：

NEUROREPORT | 2003年 / 14卷 / 10期

基金：

巴西圣保罗研究基金会;

关键词：

age; behavior; cellular prion protein; locomotor activity; short- and long-term memory;

D O I：

10.1097/01.wnr.0000078541.07662.90

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cellular prion protein (PrPc) has been associated with some physiological functions in recent reports. Here we investigate behavioral parameters in 3- and 9-month-old mice lacking PrPc protein (Prnp(0/0)) and in rats after intrahippocampal administration of affinity purified anti-PrPc IgG (0.09 mug/side). No differences were observed between 3-month-old animals. However, 9-month-old Prnp(0/0) mice and rats infused with anti-PrPc antibody showed a clear impairment of short- and long-term memory retention of a step-down inhibitory avoidance task. A decreased locomotor activity during exploration of an open field was also observed. These results suggest that systems involved in memory formation become more susceptible to mechanisms that require PrPc between the ages of 3 and 9 months in both mice and rats.

引用

页码：1375 / 1379

页数：5