Pyrocoll, an antibiotic, antiparasitic and antitumor compound produced by a novel alkaliphilic Streptomyces strain

被引：65

作者：

Dieter, A

Fiedler, HP

Goodfellow, M

Müller, WEG

Brun, R

Beil, W

Bringmann, G

机构：

[1] Univ Tubingen, Inst Mikrobiol, D-72076 Tubingen, Germany

[2] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany

[3] Univ Newcastle Upon Tyne, Sch Biol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[4] Univ Mainz, Inst Physiol Chem, Angew Mol Biol Abt, D-55099 Mainz, Germany

[5] Schweizer Tropeninst, CH-4002 Basel, Switzerland

[6] Hannover Med Sch, Inst Pharmakol, D-30625 Hannover, Germany

来源：

JOURNAL OF ANTIBIOTICS | 2003年 / 56卷 / 07期

关键词：

D O I：

10.7164/antibiotics.56.639

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new secondary metabolite was detected in the culture extract of Streptomyces sp. AK 409 by HPLC-diode-array screening. The metabolite was identified as pyrocoll, which is known to be a constituent of cigarette smoke. Pyrocoll is known as a synthetic compound, but until now had not been isolated as a natural product from a microorganism. The compound showed biological activity against various Arthrobacter strains, filamentous fungi, several pathogenic protozoa, and some human tumor cell lines.

引用

页码：639 / 646

页数：8

共 29 条

[1]

[Anonymous], 1993, NAT PROD LETT

[2] CULTIVATION IN A SEMI-DEFINED MEDIUM OF ANIMAL INFECTIVE FORMS OF TRYPANOSOMA-BRUCEI, TRYPANOSOMA-EQUIPERDUM, TRYPANOSOMA-EVANSI, TRYPANOSOMA-RHODESIENSE AND T-GAMBIENSE [J].