Ripromycin and other polycyclic macrolactams from Streptomyces sp Tu 6239:: Taxonomy, fermentation, isolation and biological properties

被引：26

作者：

Bertasso, M

Holzenkämpfer, M

Zeeck, A

Stackebrandt, E

Beil, W

Fiedler, HP

机构：

[1] Univ Tubingen, Inst Mikrobiol, D-72076 Tubingen, Germany

[2] Univ Gottingen, Inst Organ Chem, D-37077 Gottingen, Germany

[3] Deutsch Sammlung Mikroorganismen & Zellkulturen G, D-38124 Braunschweig, Germany

[4] Hannover Med Sch, Inst Pharmakol, D-30625 Hannover, Germany

来源：

JOURNAL OF ANTIBIOTICS | 2003年 / 56卷 / 04期

关键词：

D O I：

10.7164/antibiotics.56.364

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Strain Tu 6239 was isolated from a soil sample collected in Brazil and determined as a new species of the genus Streptomyces. In the course of our HPLC-diode array screening program three metabolites were detected in the culture filtrate and mycelium extracts of strain Tu 6239. They were characterised as members of the macrolactam group, the new compound ripromycin (1), the previously described ikarugamycin (2) and a new derivative of it, ikarugamycin epoxide (3). They show antibiotic activities against Gram-positive bacteria and cytostatic effects to various human tumor cell lines.

引用

页码：364 / 371

页数：8

共 22 条

[1] CAPSIMYCIN, A NEW ANTIBIOTIC .1. PRODUCTION, ISOLATION AND PROPERTIES [J].