Successful treatment of a patient with Takayasu arteritis using a humanized anti-interleukin-6 receptor antibody

被引：158

作者：

Nishimoto, Norihiro ^{[1
]}

Nakahara, Hideko ^{[2
]}

Yoshio-Hoshino, Naoko ^{[1
]}

Mima, Toru ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Frontier Biosci, Lab Immune Regulat, Suita, Osaka 5650871, Japan

[2] NTT W Osaka Hosp, Osaka, Japan

来源：

ARTHRITIS AND RHEUMATISM | 2008年 / 58卷 / 04期

关键词：

D O I：

10.1002/art.23373

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Takayasu arteritis (TA) is a chronic inflammatory disease that involves the aorta and its major branches. Since overproduction of interleukin-6 (IL-6) seems to play a pathogenic role in TA, we used the anti-IL-6 receptor (IL-6R) antibody tocilizumab to treat a 20-year-old woman with refractory active TA complicated by ulcerative colitis (UC). Treatment with tocilizumab improved the clinical manifestations of TA and the abnormal laboratory findings in this patient and ameliorated the activity of UC. These results indicate that IL-6R inhibition with tocilizumab might be a future treatment option for TA.

引用

页码：1197 / 1200

页数：4

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