The β-glucuronidase klotho hydrolyzes and activates the TRPV5 channel

被引：493

作者：

Chang, Q ^{[1
]}

Hoefs, S ^{[1
]}

van der Kemp, AW ^{[1
]}

Topala, CN ^{[1
]}

Bindels, RJ ^{[1
]}

Hoenderop, JG ^{[1
]}

机构：

[1] Radboud Univ Nijmegen Med Ctr, Nijmegen Ctr Mol Life Sci, Dept Physiol, NL-6500 HB Nijmegen, Netherlands

来源：

SCIENCE | 2005年 / 310卷 / 5747期

关键词：

D O I：

10.1126/science.1114245

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Blood calcium concentration is maintained within a narrow range despite large variations in dietary input and body demand. The Transient Receptor Potential ion channel TRPV5 has been implicated in this process. We report here that TRPV5 is stimulated by the mammalian hormone klotho. Klotho, a beta-glucuronidase, hydrolyzes extracellular sugar residues on TRPV5, entrapping the channel in the plasma membrane. This maintains durable calcium channel activity and membrane calcium permeability in kidney. Thus, klotho activates a cell surface channel by hydrolysis of its extracellular N-linked oligosaccharides.

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页码：490 / 493

页数：4

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