Therapeutic intervention with inhibitors of co-stimulatory pathways in autoimmune disease

被引：30

作者：

Aruffo, A ^{[1
]}

Hollenbaugh, D ^{[1
]}

机构：

[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, Immunol & Inflammat Drug Discovery, Princeton, NJ 08543 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 06期

关键词：

D O I：

10.1016/S0952-7915(01)00279-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Many humanized antibodies and fusion proteins targeting T-cell co-stimulatory molecules are now in late-stage clinical development (phase II, phase III) or have recently completed phase III clinical trials. Both Amevive, an LFA-3-Ig fusion protein targeting CD2, and Xanelim, a humanized anti-CD11a antibody, have shown efficacy in pivotal phase III trials in patients with plaque psoriasis. These new medicines are poised to enter clinical use in 2002.

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页码：683 / 686

页数：4

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