EZH2 mutations and their association with PICALM-MLLT10 positive acute leukaemia

被引:21
作者
Grossmann, Vera [1 ]
Bacher, Ulrike [2 ]
Kohlmann, Alexander [1 ]
Artusi, Valentina [1 ]
Klein, Hans-Ulrich [3 ]
Dugas, Martin [3 ]
Schnittger, Susanne [1 ]
Alpermann, Tamara [1 ]
Kern, Wolfgang [1 ]
Haferlach, Torsten [1 ]
Haferlach, Claudia [1 ]
机构
[1] MLL Munich Leukaemia Lab, Munich, Germany
[2] Univ Hamburg, Dept Stem Cell Transplantat, Hamburg, Germany
[3] Univ Munster, Dept Med Informat & Biomath, D-4400 Munster, Germany
关键词
EZH2; mutations; t(10; 11)(p13; (q14)); PICALM-MLLT10; rearrangement; T-cell acute lymphoblastic leukaemia; lymphoma (T-ALL); DNMT3A mutations; deep-sequencing; METHYLTRANSFERASE GENE EZH2; MYELODYSPLASTIC SYNDROMES; SOMATIC MUTATIONS; DNMT3A MUTATIONS;
D O I
10.1111/j.1365-2141.2011.08986.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:387 / 390
页数:4
相关论文
共 9 条
[1]   Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders [J].
Ernst, Thomas ;
Chase, Andrew J. ;
Score, Joannah ;
Hidalgo-Curtis, Claire E. ;
Bryant, Catherine ;
Jones, Amy V. ;
Waghorn, Katherine ;
Zoi, Katerina ;
Ross, Fiona M. ;
Reiter, Andreas ;
Hochhaus, Andreas ;
Drexler, Hans G. ;
Duncombe, Andrew ;
Cervantes, Francisco ;
Oscier, David ;
Boultwood, Jacqueline ;
Grand, Francis H. ;
Cross, Nicholas C. P. .
NATURE GENETICS, 2010, 42 (08) :722-U109
[2]   Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in >80% of patients with TET2 and EZH2 being of high prognostic relevance [J].
Grossmann, V. ;
Kohlmann, A. ;
Eder, C. ;
Haferlach, C. ;
Kern, W. ;
Cross, N. C. P. ;
Haferlach, T. ;
Schnittger, S. .
LEUKEMIA, 2011, 25 (05) :877-879
[3]   High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia [J].
Gutierrez, Alejandro ;
Sanda, Takaomi ;
Grebliunaite, Ruta ;
Carracedo, Arkaitz ;
Salmena, Leonardo ;
Ahn, Yebin ;
Dahlberg, Suzanne ;
Neuberg, Donna ;
Moreau, Lisa A. ;
Winter, Stuart S. ;
Larson, Richard ;
Zhang, Jianhua ;
Protopopov, Alexei ;
Chin, Lynda ;
Pandolfi, Pier Paolo ;
Silverman, Lewis B. ;
Hunger, Stephen P. ;
Sallan, Stephen E. ;
Look, A. Thomas .
BLOOD, 2009, 114 (03) :647-650
[4]   DNMT3A Mutations in Acute Myeloid Leukemia. [J].
Ley, Timothy J. ;
Ding, Li ;
Walter, Matthew J. ;
McLellan, Michael D. ;
Lamprecht, Tamara ;
Larson, David E. ;
Kandoth, Cyriac ;
Payton, Jacqueline E. ;
Baty, Jack ;
Welch, John ;
Harris, Christopher C. ;
Lichti, Cheryl F. ;
Townsend, R. Reid ;
Fulton, Robert S. ;
Dooling, David J. ;
Koboldt, Daniel C. ;
Schmidt, Heather ;
Zhang, Qunyuan ;
Osborne, John R. ;
Lin, Ling ;
O'Laughlin, Michelle ;
McMichael, Joshua F. ;
Delehaunty, Kim D. ;
McGrath, Sean D. ;
Fulton, Lucinda A. ;
Magrini, Vincent J. ;
Vickery, Tammi L. ;
Hundal, Jasreet ;
Cook, Lisa L. ;
Conyers, Joshua J. ;
Swift, Gary W. ;
Reed, Jerry P. ;
Alldredge, Patricia A. ;
Wylie, Todd ;
Walker, Jason ;
Kalicki, Joelle ;
Watson, Mark A. ;
Heath, Sharon ;
Shannon, William D. ;
Varghese, Nobish ;
Nagarajan, Rakesh ;
Westervelt, Peter ;
Tomasson, Michael H. ;
Link, Daniel C. ;
Graubert, Timothy A. ;
DiPersio, John F. ;
Mardis, Elaine R. ;
Wilson, Richard K. .
NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (25) :2424-2433
[5]   Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies [J].
Makishima, H. ;
Jankowska, A. M. ;
Tiu, R. V. ;
Szpurka, H. ;
Sugimoto, Y. ;
Hu, Z. ;
Saunthararajah, Y. ;
Guinta, K. ;
Keddache, M. A. ;
Putnam, P. ;
Sekeres, M. A. ;
Moliterno, A. R. ;
List, A. F. ;
McDevitt, M. A. ;
Maciejewski, J. P. .
LEUKEMIA, 2010, 24 (10) :1799-1804
[6]   Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin [J].
Morin, Ryan D. ;
Johnson, Nathalie A. ;
Severson, Tesa M. ;
Mungall, Andrew J. ;
An, Jianghong ;
Goya, Rodrigo ;
Paul, Jessica E. ;
Boyle, Merrill ;
Woolcock, Bruce W. ;
Kuchenbauer, Florian ;
Yap, Damian ;
Humphries, R. Keith ;
Griffith, Obi L. ;
Shah, Sohrab ;
Zhu, Henry ;
Kimbara, Michelle ;
Shashkin, Pavel ;
Charlot, Jean F. ;
Tcherpakov, Marianna ;
Corbett, Richard ;
Tam, Angela ;
Varhol, Richard ;
Smailus, Duane ;
Moksa, Michelle ;
Zhao, Yongjun ;
Delaney, Allen ;
Qian, Hong ;
Birol, Inanc ;
Schein, Jacqueline ;
Moore, Richard ;
Holt, Robert ;
Horsman, Doug E. ;
Connors, Joseph M. ;
Jones, Steven ;
Aparicio, Samuel ;
Hirst, Martin ;
Gascoyne, Randy D. ;
Marra, Marco A. .
NATURE GENETICS, 2010, 42 (02) :181-U124
[7]   Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes [J].
Nikoloski, Gorica ;
Langemeijer, Saskia M. C. ;
Kuiper, Roland P. ;
Knops, Ruth ;
Massop, Marion ;
Tonnissen, Evelyn R. L. T. M. ;
van der Heijden, Adrian ;
Scheele, Theresia N. ;
Vandenberghe, Peter ;
de Witte, Theo ;
van der Reijden, Bert A. ;
Jansen, Joop H. .
NATURE GENETICS, 2010, 42 (08) :665-667
[8]   Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L [J].
Okada, Yuki ;
Jiang, Qi ;
Lemieux, Margot ;
Jeannotte, Lucie ;
Su, Lishan ;
Zhang, Yi .
NATURE CELL BIOLOGY, 2006, 8 (09) :1017-U105
[9]   Recurrent DNMT3A mutations in patients with myelodysplastic syndromes [J].
Walter, M. J. ;
Ding, L. ;
Shen, D. ;
Shao, J. ;
Grillot, M. ;
McLellan, M. ;
Fulton, R. ;
Schmidt, H. ;
Kalicki-Veizer, J. ;
O'Laughlin, M. ;
Kandoth, C. ;
Baty, J. ;
Westervelt, P. ;
DiPersio, J. F. ;
Mardis, E. R. ;
Wilson, R. K. ;
Ley, T. J. ;
Graubert, T. A. .
LEUKEMIA, 2011, 25 (07) :1153-1158