Phagocytosis and killing of Streptococcus suis by porcine neutrophils

被引：140

作者：

Chabot-Roy, Genevieve ^{[1
]}

Willson, Philip ^{[2
]}

Segura, Mariela ^{[1
]}

Lacouture, Sonia ^{[1
]}

Gottschalk, Marcelo ^{[1
]}

机构：

[1] Univ Montreal, Fac Med Vet, GREMIP, St Hyacinthe, PQ J2S 2M2, Canada

[2] Univ Saskatchewan, Vaccine & Infect Dis Org, Saskatoon, SK S7N 5E3, Canada

来源：

MICROBIAL PATHOGENESIS | 2006年 / 41卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Streptococcus suis; Neutrophils; Opsonic phagocytosis; Killing; Polysaccharide capsule; Suilysin;

D O I：

10.1016/j.micpath.2006.04.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Streptococcus suis serotype 2 is an important swine pathogen responsible for diverse infections, mainly meningitis. Virulence factors and the pathogenesis of infection are not well understood. Neutrophils may play an important role in the pathogenesis of infection given that infiltration by neutrophils and mononuclear cells are frequently observed in lesions caused by S. suis. The objective of this work was to Study the interactions between S. suis serotype 2 and porcine neutrophils. Results showed that suilysin is toxic to neutrophils and this could help S. suis evade innate immunity. Moreover, suilysin appears to affect complement-dependent killing by decreasing the opsonization of S. suis and the bactericidal capacity of neutrophils. Our results confirm that capsule polysaccharide protects S. suis against killing and phagocytosis by neutrophils. We also showed that the presence of specific IgG against S. suis serotype 2 promoted killing by neutrophils, indicating that the induction of a strong humoral response is beneficial for clearance of this pathogen. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：21 / 32

页数：12

共 71 条

[61] Epidemiological relationship of human and swine Streptococcus suis isolates [J].

Tarradas, C ;

Luque, I ;

de Andrés, D ;

Shahein, YEAA ;

Pons, P ;

González, F ;

Borge, C ;

Perea, A .

JOURNAL OF VETERINARY MEDICINE SERIES B-INFECTIOUS DISEASES AND VETERINARY PUBLIC HEALTH, 2001, 48 (05) :347-355

[62] β-hemolysin-independent induction of apoptosis of macrophages infected with serotype III group B streptococcus [J].

Ulett, GC ;

Bohnsack, JF ;

Armstrong, J ;

Adderson, EE .

JOURNAL OF INFECTIOUS DISEASES, 2003, 188 (07) :1049-1053

[63] Invasion of porcine brain microvascular endothelial cells by Streptococcus suis serotype 2 [J].

Vanier, G ;

Segura, M ;

Friedl, P ;

Lacouture, S ;

Gottschalk, M .

INFECTION AND IMMUNITY, 2004, 72 (03) :1441-1449

[64]

VECHT U, 1989, AM J VET RES, V50, P1037

[65] Fluorescent labels influence phagocytosis of Bordetella pertussis by human neutrophils [J].

Weingart, CL ;

Broitman-Maduro, G ;

Dean, G ;

Newman, S ;

Peppler, M ;

Weiss, AA .

INFECTION AND IMMUNITY, 1999, 67 (08) :4264-4267

[66]

*WHO, 2005, WHO OUTBR ASS STREPT

[67] RELATION BETWEEN ENCAPSULATION AND VARIOUS PROPERTIES OF STREPTOCOCCUS-SUIS [J].

WIBAWAN, IWT ;

LAMMLER, C .

JOURNAL OF VETERINARY MEDICINE SERIES B-INFECTIOUS DISEASES AND VETERINARY PUBLIC HEALTH, 1994, 41 (7-8) :453-459

[68] PATHOGENESIS OF MENINGITIS CAUSED BY STREPTOCOCCUS-SUIS TYPE-2 [J].

WILLIAMS, AE ;

BLAKEMORE, WF .

JOURNAL OF INFECTIOUS DISEASES, 1990, 162 (02) :474-481

[69] Identification and characterization of two temperature-induced surface-associated proteins of Streptococcus suis with high homologies to members of the arginine deiminase system of Streptococcus pyogenes [J].

Winterhoff, N ;

Goethe, R ;

Gruening, P ;

Rohde, M ;

Kalisz, H ;

Smith, HE ;

Valentin-Weigand, P .

JOURNAL OF BACTERIOLOGY, 2002, 184 (24) :6768-6776

[70] Neutrophils: Molecules, functions and pathophysiological aspects [J].

Witko-Sarsat, V ;

Rieu, P ;

Descamps-Latscha, B ;

Lesavre, P ;

Halbwachs-Mecarelli, L .

LABORATORY INVESTIGATION, 2000, 80 (05) :617-653

← 1 2 3 4 5 6 7 8 →