Synthesis of cis- and trans-5,8-dihydroxy-5,6,7,8-tetrahydro-1,4-naphthoquinone

被引：3

作者：

Arima, S

Konda, YY

Takeda, K

Takayanagi, H

Harigaya, Y

机构：

[1] Kitasato Univ, Sch Pharmaceut Sci, Minato Ku, Tokyo 1088641, Japan

[2] EBARA Res Co Ltd, Ctr Adv Technol, Fujisawa, Kanagawa 2518502, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2001年 / 49卷 / 10期

关键词：

naphthoquinone; spiroacetal-bridged compound; antitumor activity;

D O I：

10.1248/cpb.49.1340

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cis- and trans-5,8-dihydroxy-5,6,7,8-tetrahydro-1,4-naphthoquinone (la, 1b) were for the first time synthesized from 5,8-dihydroxy-1,4-naphthoquinone (naphthazazine) (6) as a starting material and racemic triol (3) was first synthesized from 7. The configuration of la was determined by X-ray analysis.

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页码：1340 / 1342

页数：3

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