Autoimmune thyroid diseases and Helicobacter pylori: The correlation is present only in Graves's disease

被引：49

作者：

Bassi, Vincenzo ^{[1
]}

Marino, Gennaro ^{[1
]}

Iengo, Alba ^{[2
]}

Fattoruso, Olimpia ^{[2
]}

Santinelli, Crescenzo ^{[1
]}

机构：

[1] San Giovanni Bosco Hosp, UOC Med Interna, Ctr ASL Na 1, I-80144 Naples, Italy

[2] San Giovanni Bosco Hosp, UOC Patol Gen, ASL Na Centro 1, I-80144 Naples, Italy

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2012年 / 18卷 / 10期

关键词：

Autoimmunity; Cag-A; Graves' disease; Hashimoto's thyroiditis; Helicobacter pylori; Hyperthyroidism; Hypothyroidism; INFECTION; BINDING; AUTOANTIBODIES; ANTIBODIES; HASHIMOTOS; PROTEINS;

D O I：

10.3748/wjg.v18.i10.1093

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

AIM: To investigate the correlation between autoimmune thyroid diseases (ATDs) and the prevalence of Cag-A positive strains of Helicobacter pylori (H. pylori) in stool samples. METHODS: Authors investigated 112 consecutive Caucasian patients (48 females and 4 males with Graves' disease and 54 females and 6 males with Hashimoto's thyroiditis HT), at their first diagnosis of ATDs. Authors tested for H. pylori in stool samples using an amplified enzyme immunoassay and Cag-A in serum samples using an enzyme-linked immunoassay method (ELISA). The results were analyzed using the two-sided Fisher's exact test and the respective odds ratio (OR) was calculated. RESULTS: A marked correlation was found between the presence of H. pylori (P <= 0.0001, OR 6.3) and, in particular, Cag-A positive strains (P <= 0.005, OR 5.3) in Graves' disease, but not in Hashimoto's thyroiditis, where authors found only a correlation with Cag-A strains (P <= 0.005, OR 8.73) but not when H. pylori was present. CONCLUSION: The marked correlation between H. pylori and Cag-A, found in ATDs, could be dependent on the different expression of adhesion molecules in the gastric mucosa. (c) 2012 Baishideng. All rights reserved.

引用

页码：1093 / 1097

页数：5

共 31 条

[1]

Functional adaptation of BabA, the H-pylori ABO blood group antigen binding adhesin [J].

Aspholm-Hurtig, M ;

Dailide, G ;

Lahmann, M ;

Kalia, A ;

Ilver, D ;

Roche, N ;

Vikström, S ;

Sjöström, R ;

Lindén, S ;

Bäckström, A ;

Lundberg, C ;

Arnqvist, A ;

Mahdavi, J ;

Nilsson, UJ ;

Velapatiño, B ;

Gilman, RH ;

Gerhard, M ;

Alarcon, T ;

López-Brea, M ;

Nakazawa, T ;

Fox, JG ;

Correa, P ;

Dominguez-Bello, MG ;

Perez-Perez, GI ;

Blaser, MJ ;

Normark, S ;

Carlstedt, I ;

Oscarson, S ;

Teneberg, S ;

Berg, DE ;

Borén, T .

SCIENCE, 2004, 305 (5683) :519-522

[2]

Atherton JC, 1998, BRIT MED BULL, V54, P105

[3]

Identification of a Correlation between Helicobacter pylori Infection and Graves' Disease [J].

Bassi, Vincenzo ;

Santinelli, Crescenzo ;

Iengo, Alba ;

Romano, Carmela .

HELICOBACTER, 2010, 15 (06) :558-562

[4]

Cytotoxic T Cells in H. pylori-Related Gastric Autoimmunity and Gastric Lymphoma [J].

Bergman, Mathijs P. ;

D'Elios, Mario M. .

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2010,

[5]

Decrease in thyroid autoantibodies after eradication of Helicobacter pylori infection [J].

Bertalot, G ;

Montresor, G ;

Tampieri, M ;

Spasiano, A ;

Pedroni, M ;

Milanesi, B ;

Favret, M ;

Manca, N ;

Negrini, R .

CLINICAL ENDOCRINOLOGY, 2004, 61 (05) :650-652

[6]

ATTACHMENT OF HELICOBACTER-PYLORI TO HUMAN GASTRIC EPITHELIUM MEDIATED BY BLOOD-GROUP ANTIGENS [J].

BOREN, T ;

FALK, P ;

ROTH, KA ;

LARSON, G ;

NORMARK, S .

SCIENCE, 1993, 262 (5141) :1892-1895

[7]

THYROTROPIN (TSH)-BINDING PROTEINS IN BACTERIA AND THEIR CROSS-REACTION WITH AUTOANTIBODIES AGAINST THE HUMAN TSH RECEPTOR [J].

BYFIELD, PGH ;

DAVIES, SC ;

COPPING, S ;

BARCLAY, FE ;

BORRIELLO, SP .

JOURNAL OF ENDOCRINOLOGY, 1989, 121 (03) :571-577

[8]

Gastric autoimmunity:: the role of Helicobacter pylori and molecular mimicry [J].

D'Elios, MM ;

Appelmelk, BJ ;

Amedei, A ;

Bergman, MP ;

Del Prete, G .

TRENDS IN MOLECULAR MEDICINE, 2004, 10 (07) :316-323

[9]

Helicobacter pylori infection is markedly increased in patients with autoimmune atrophic thyroiditis [J].

de Luis, DA ;

Varela, C ;

de La Calle, H ;

Cantón, R ;

de Argila, CM ;

San Roman, AL ;

Boixeda, D .

JOURNAL OF CLINICAL GASTROENTEROLOGY, 1998, 26 (04) :259-263

[10]

Histomorphological aspects of the development of thyroid autoimmune diseases: Consequences for our understanding of endocrine ophthalmopathy [J].

Delemarre, FGA ;

Simons, PJ ;

Drexhage, HA .

THYROID, 1996, 6 (04) :369-377

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